{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:57Z","timestamp":1787013897962,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,8,28]],"date-time":"2016-08-28T00:00:00Z","timestamp":1472342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of the present study was to investigate the frequency of abnormal clinicopathological parameters in a population of client\u2010owned clinically healthy middle\u2010aged dogs and cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Biochemical and haematological profiles, urinalysis and total\n                      <jats:styled-content style=\"fixed-case\">T4<\/jats:styled-content>\n                      were measured in clinically healthy middle\u2010aged dogs (age, 5\u20138 years) and cats (age, 6\u20139 years) presenting to veterinary practices for routine procedures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 406 dogs, only 55 had no abnormalities identified in the testing panel. Most changes were minor or considered artifactual; however, changes that were diagnostic of significant disease or warranting additional evaluation were identified in 25 dogs (6.2%). Of the 130 cats, only 26 had no abnormalities identified in the testing panel. Most changes were minor or considered artifactual; however, changes diagnostic of significant disease or warranting additional evaluation were identified in 25 cats (19.2%). Significant abnormalities included anaemia, inflammation and evidence of liver, kidney and pancreatic disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Biochemical and haematological testing as part of regular preventive health checks may facilitate early detection of diseases before they present clinically, allowing earlier intervention and better health outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/avj.12481","type":"journal-article","created":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T00:55:19Z","timestamp":1472432119000},"page":"317-323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Prevalence of clinicopathological changes in healthy middle\u2010aged dogs and cats presenting to veterinary practices for routine procedures"],"prefix":"10.1111","volume":"94","author":[{"given":"D","family":"Dell'Osa","sequence":"first","affiliation":[{"name":"IDEXX Laboratories Pty Ltd  Rydalmere NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Jaensch","sequence":"additional","affiliation":[{"name":"IDEXX Laboratories Pty Ltd  Rydalmere NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2007.00364.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2012.01247.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4102\/jsava.v78i1.283"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2009.07.011"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5326\/0410081"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.239.5.625"},{"key":"e_1_2_8_8_1","volume-title":"Standards of care","author":"ASAVA","year":"2013"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2002.tb02350.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X12464628"},{"key":"e_1_2_8_11_1","first-page":"626","article-title":"Ultrasonic and laboratory screening in clinically normal mature golden retriever dogs","volume":"53","author":"Webb J","year":"2012","journal-title":"Can Vet J"},{"key":"e_1_2_8_12_1","first-page":"55","article-title":"Erythocyte macrocytosis in miniature poodles","volume":"30","author":"Schalm O.","year":"1976","journal-title":"Canine Pract"},{"key":"e_1_2_8_13_1","unstructured":"International Renal Interest Society. IRIS staging of chronic kidney disease (CKD).http:\/\/www.iris\u2010kidney.com\/. 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