{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:53:27Z","timestamp":1763747607537},"reference-count":8,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T00:00:00Z","timestamp":1485388800000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Histiocytic sarcomas (<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>) frequently metastasise, most commonly to visceral sites, but also to regional lymph nodes. Nodal metastases are associated with a poorer prognosis. This retrospective study aimed to evaluate prognostic factors, including the effect of adjuvant chemotherapy, on survival in dogs with nodal, but not systemic, metastases from <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective case series of 12 dogs with histologically diagnosed <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> metastatic to lymph nodes treated with surgery with and without adjuvant chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All dogs had histological evidence of metastasis to lymph nodes, with no clinical evidence for metastasis to viscera. Eight dogs that received chemotherapy had a median estimated survival of 219 days (range 77\u20131638 days); 1\u2010 and 2\u2010year estimated survival rates were 37.7%. Median survival time for 4 dogs with nodal metastases that did not receive chemotherapy was 57 days (range 39\u2013136 days) with none alive 1 year after surgery<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Survival for dogs with only regional nodal metastases from <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> appeared to be improved by adjuvant chemotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/avj.12522","type":"journal-article","created":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T05:50:21Z","timestamp":1485409821000},"page":"37-40","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Chemotherapy for dogs with lymph node metastasis from histiocytic sarcomas"],"prefix":"10.1111","volume":"95","author":[{"given":"AS","family":"Moore","sequence":"first","affiliation":[{"name":"Veterinary Oncology Consultants  379 Lake Innes Drive, Wauchope New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DP","family":"Taylor","sequence":"additional","affiliation":[{"name":"Vetnostics Macquarie Park  NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Reppas","sequence":"additional","affiliation":[{"name":"Vetnostics Macquarie Park  NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AE","family":"Frimberger","sequence":"additional","affiliation":[{"name":"Veterinary Oncology Consultants  379 Lake Innes Drive, Wauchope New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-1-74"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-1-66"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5810.2006.00090.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.239.1.90"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12354"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2010.0588.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2009.00186.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","unstructured":"SkorupskiKA CliffordCA PaoloniMCet al.CCNU for the treatment of dogs with histiocytic sarcoma.2007;21:121\u2013126.","DOI":"10.1111\/j.1939-1676.2007.tb02937.x"}],"container-title":["Australian Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Favj.12522","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/avj.12522","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:01:15Z","timestamp":1696338075000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/avj.12522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":8,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/avj.12522"],"URL":"https:\/\/doi.org\/10.1111\/avj.12522","archive":["Portico"],"relation":{},"ISSN":["0005-0423","1751-0813"],"issn-type":[{"value":"0005-0423","type":"print"},{"value":"1751-0813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2015-08-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}