{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:35:03Z","timestamp":1767897303847,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T00:00:00Z","timestamp":1490572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Case report<\/jats:title><jats:p>A 4\u2010year\u2010old neutered male Rhodesian Ridgeback dog with right\u2010sided Horner's syndrome, bilateral laryngeal paralysis, neck pain and bilateral hindlimb ataxia was euthanased following deterioration of its neurological status. Necropsy examination revealed an off\u2010white retropharyngeal neoplastic mass (100\u2009\u00d7\u200930\u2009\u00d7\u200930\u2009mm) attached to the base of the skull on the right side and macroscopic nodular metastases in the spleen and three vertebral bodies (<jats:styled-content style=\"fixed-case\">C6<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">C7<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">T6<\/jats:styled-content>), including a nodule attached to the dura at<jats:styled-content style=\"fixed-case\">C7<\/jats:styled-content>. Histological evidence of neuroblastic tumour was detected in these macroscopic lesions, a regional lymph node, bone marrow of a femur and all 15 vertebral bodies (<jats:styled-content style=\"fixed-case\">C1\u2013T8<\/jats:styled-content>) examined, including the three with macroscopic metastases, and in the lumens of small blood vessels in the lungs and liver. Ganglion cell differentiation was detected only in the primary retropharyngeal mass, one splenic nodule and the<jats:styled-content style=\"fixed-case\">C7<\/jats:styled-content>dural nodule. Neoplastic cells were immunoreactive to neurofilament protein (ganglion cells only), vimentin and synaptophysin, and were negative for<jats:styled-content style=\"fixed-case\">S100<\/jats:styled-content>protein,<jats:styled-content style=\"fixed-case\">GFAP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">CD3<\/jats:styled-content>and Pax5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The diagnosis was disseminated peripheral neuroblastoma, differentiating subtype (International Neuroblastoma Pathology Classification), with likely primary involvement of the right cranial cervical ganglion. 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