{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:11:35Z","timestamp":1791087095544,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,8,27]],"date-time":"2017-08-27T00:00:00Z","timestamp":1503792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Winifred Violet Scott Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Because of limited availability of chloramphenicol to veterinary suppliers, a preliminary study was performed to predict whether an analogue, florfenicol, is an efficacious treatment for chlamydiosis in koalas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Florfenicol was administered to koalas with naturally occurring chlamydiosis at 20\u2009mg\/kg SC (n\u2009=\u20093) and at 5\u2009mg\/kg (n\u2009=\u20093) and 10\u2009mg\/kg (n\u2009=\u20093) IV. The estimated areas under the plasma concentration versus time curves (AUC) were compared with the minimum inhibitory concentration to inhibit <jats:italic>Chlamydia pecorum<\/jats:italic>. Clinical data were also examined from field trials conducted on koalas (n\u2009=\u200919) with naturally occurring chlamydiosis and treated with florfenicol at a range of dosages (5\u201320\u2009mg\/kg SC and 6\u201315\u2009mg\/kg IV). Florfenicol binding to proteins in plasma was also determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Florfenicol was not detectable in plasma 24\u2009h post\u2010administration at 20\u2009mg\/kg SC. The estimated AUC<jats:sub>0\u201324\u2009h<\/jats:sub> following administration at 10\u2009mg\/kg IV suggests florfenicol might be effective against <jats:italic>Chlamydia<\/jats:italic> spp. via this route. Florfenicol binding to plasma proteins was 13.0% (\u00b1 0.30 SEM).<\/jats:p><jats:p>After treatment with florfenicol in field trials, 5 of 19 koalas (26%) were released without further treatment, 4 with no long\u2010term follow\u2010up; 6 (32%) required additional treatment with chloramphenicol to resolve chlamydiosis; 7 (36%) failed to clinically improve, of which 3 had clinical signs and\/or necropsy findings suggestive of antibiotic\u2010related gastrointestinal dysbiosis; another koala died within minutes of florfenicol administered IV at 7\u2009mg\/kg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>When administered at dosages tolerable in the field, florfenicol is a problematic treatment for chlamydiosis based on equivocal outcomes and plasma concentrations below those that inhibit the pathogen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/avj.12617","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T09:18:22Z","timestamp":1504171102000},"page":"343-349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Assessment of florfenicol as a possible treatment for chlamydiosis in koalas (<scp><i>Phascolarctos cinereus<\/i><\/scp>)"],"prefix":"10.1111","volume":"95","author":[{"given":"C","family":"Budd","sequence":"first","affiliation":[{"name":"Sydney School of Veterinary Science The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Port Macquarie Koala Hospital  Port Macquarie New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Gillett","sequence":"additional","affiliation":[{"name":"Australia Zoo Wildlife Hospital  Beerwah Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Hanger","sequence":"additional","affiliation":[{"name":"Endeavour Veterinary Ecology  Toorbul Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JJ","family":"Loader","sequence":"additional","affiliation":[{"name":"Endeavour Veterinary Ecology  Toorbul Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Govendir","sequence":"additional","affiliation":[{"name":"Sydney School of Veterinary Science The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2013.02.026"},{"key":"e_1_2_9_3_1","first-page":"799","article-title":"Characteristics of the Chlamydia trachomatis species \u2010 immunopathology and infections","volume":"21","author":"Choroszy\u2010Kr\u00f3l I","year":"2012","journal-title":"Adv Clin Exp Med"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2015.999041"},{"key":"e_1_2_9_5_1","first-page":"192","volume-title":"Dirty tail and other chlamydial diseases in koalas. 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