{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T13:22:43Z","timestamp":1784812963098,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T00:00:00Z","timestamp":1524528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012895","name":"Zoetis","doi-asserted-by":"crossref","award":["20844"],"award-info":[{"award-number":["20844"]}],"id":[{"id":"10.13039\/100012895","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the antibody responses to a commercial Hendra virus vaccine (Equivac\u00ae HeV) in a field environment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A group of 61 horses received a primary vaccination course comprising two doses administered 3\u20136\u2009weeks apart (V1, V2) and a 3rd dose (V3) given 6\u2009months after the second. This was followed by booster vaccinations at 12 monthly intervals (V4, V5). Antibody titres were assessed using a virus\u2010neutralisation test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Neutralising antibodies against HeV were not detected prior to vaccination. Antibodies were detected in 54\/57 horses at 3\u2009weeks after V1 and 51\/51 had titres \u2265\u200932 at 8\u2009weeks after V2. At 6\u2009months after V2, antibody titres decreased in most (31\/34) horses and were not detected in three horses. A rapid increase in antibody titres was recorded in 35\/36 horses at 1\u2009week following V3. By the first annual booster vaccination (V4), antibodies were still detectable in 29\/29 horses, although titres had decreased; in 26\/29 horses, titres remained \u2265\u200932. All horses showed an increase in antibody titres after V4. There was no statistically significant increase in mean antibody titre after V5, compared with after V4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Horses administered Equivac\u00ae HeV, using a primary vaccination course followed by annual booster vaccinations, mounted an effective secondary immune response and acquired antibody responses that were consistent with protective immunity against HeV in the form of virus\u2010neutralising antibodies. No adverse events were observed after vaccine administration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/avj.12694","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T05:02:17Z","timestamp":1524632537000},"page":"161-166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Virus\u2010neutralising antibody responses in horses following vaccination with Equivac\u00ae HeV: a field study"],"prefix":"10.1111","volume":"96","author":[{"given":"RHH","family":"Tan","sequence":"first","affiliation":[{"name":"College of Public Health, Medicine and Veterinary Sciences James Cook University  Townsville Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Hodge","sequence":"additional","affiliation":[{"name":"Zoetis, Veterinary Medicine Research and Development  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Klein","sequence":"additional","affiliation":[{"name":"CSIRO Australian Animal Health Laboratory  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Edwards","sequence":"additional","affiliation":[{"name":"Wellington Village Veterinary Clinic  Rowville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JA","family":"Huang","sequence":"additional","affiliation":[{"name":"Zoetis, Veterinary Medicine Research and Development  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Middleton","sequence":"additional","affiliation":[{"name":"CSIRO Australian Animal Health Laboratory  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SP","family":"Watts","sequence":"additional","affiliation":[{"name":"College of Public Health, Medicine and Veterinary Sciences James Cook University  Townsville Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/v4020280"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2003.131159"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.06.015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.11.6690-6702.2005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-10-237"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.290783"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202964"},{"key":"e_1_2_8_9_1","first-page":"381","volume-title":"Immunobiology: the immune system in health and disease","author":"Janeway CJ","year":"2001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00005-14"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.05.016"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir270"},{"key":"e_1_2_8_13_1","unstructured":"Australian Pesticides and Veterinary Medicines Authority.Summary of adverse experience reports made to the APVMA about Hendra virus vaccine.APVMA 2017.https:\/\/apvma.gov.au\/node\/15786. 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