{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:22:49Z","timestamp":1789132969922,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T00:00:00Z","timestamp":1537833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the agreement, sensitivity, specificity and accuracy of prothrombin (PT) and activated partial thromboplastin time (aPTT) using the point\u2010of\u2010care analyser SCA2000\u2122 with IDEXX Coag Dx\u2122 cartridges against a reference laboratory (STAGO Start 4\u00ae) in canine blood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Citrated blood samples from 47 dogs were submitted for PT and aPTT measurements. The STAGO was taken as the gold standard and sensitivity, specificity and accuracy were calculated. Agreement between the IDEXX and STAGO test results was compared using Bland\u2010Altman analysis and Passing\u2010Bablok regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The IDEXX cartridges had a sensitivity of 92% (95% confidence interval (CI) 62\u2013100%) and specificity of 98% (95% CI 87\u2013100%; n\u2009=\u200954 samples). aPTT sensitivity was 100% (95% CI 63\u2013100%) and specificity was 47% (95% CI 30\u201365%, n\u2009=\u200942 samples). The accuracy of IDEXX cartridges compared with the STAGO Start 4 was 96% (95% CI 91\u2013100%) for PT and 57% (95% CI 42\u201372%) for aPTT. Agreement was moderate\u2013good for PT measurements within the reference range (RR). Agreement was poor for PT measurements outside of the RR and for aPTT measurements within and outside the RR. The bias between measurements from the two machines was inconsistent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PT results from the point\u2010of\u2010care IDEXX were generally reliable for diagnosing or excluding a coagulopathy. The aPTT IDEXX sensitivity was excellent but the specificity was poor. Bland\u2010Altman analysis and Passing\u2010Bablok regression indicated an inconsistent bias between the two measurements and one measurement cannot be reliably converted to the other.<\/jats:p><\/jats:sec>","DOI":"10.1111\/avj.12746","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T04:30:36Z","timestamp":1537936236000},"page":"379-384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Agreement of point\u2010of\u2010care prothrombin and activated partial thromboplastin time in dogs with a reference laboratory"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0786-7208","authenticated-orcid":false,"given":"W","family":"Yang","sequence":"first","affiliation":[{"name":"The Animal Hospital Murdoch University, Murdoch Dr  Murdoch Western Australia 6150 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Hosgood","sequence":"additional","affiliation":[{"name":"The Animal Hospital Murdoch University, Murdoch Dr  Murdoch Western Australia 6150 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Luobikis","sequence":"additional","affiliation":[{"name":"The Animal Hospital Murdoch University, Murdoch Dr  Murdoch Western Australia 6150 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Paul","sequence":"additional","affiliation":[{"name":"Anderson Moores Veterinary Specialists Ltd  Winchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7137.1052"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(00)00138-7"},{"key":"e_1_2_8_4_1","volume-title":"Fundamentals of veterinary clinical pathology","author":"Stockham SL","year":"2008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2001.62.1455"},{"key":"e_1_2_8_6_1","first-page":"135","article-title":"Submitting canine blood for prothrombin time and partial thromboplastin time determinations","volume":"26","author":"Smalko D","year":"1985","journal-title":"Can Vet J"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2001.62.734"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12064"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12200"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.68.12.1342"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.217.1500"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12097"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(00)00288-6"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200106000-00002"}],"container-title":["Australian Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Favj.12746","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/avj.12746","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:19:24Z","timestamp":1694996364000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/avj.12746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,25]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/avj.12746"],"URL":"https:\/\/doi.org\/10.1111\/avj.12746","archive":["Portico"],"relation":{},"ISSN":["0005-0423","1751-0813"],"issn-type":[{"value":"0005-0423","type":"print"},{"value":"1751-0813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,25]]},"assertion":[{"value":"2017-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}