{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:57:19Z","timestamp":1788814639455,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy of the non\u2010steroidal anti\u2010inflammatory drug, meloxicam, in alleviating pain and inflammation and on production\u2010related variables in a model of sterile acute inflammation in sheep.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Groups of 12 mature Merino ewes received 0, 0.5, 1.0 or 1.5 mg\/kg meloxicam subcutaneously 90 min before injection of 0.1 mL turpentine subcutaneously on the anterior aspect of the proximal phalanx of a forelimb. Pain\u2010 and inflammation\u2010related variables were assessed at \u221218, 3, 6, 9, 12, 24, 48 and 72 h relative to meloxicam administration. Daily feed intake and body weight change 7 days later were also assessed. Pain\u2010related variables measured were weight borne on each forelimb, lameness score, time each forelimb was raised in a 20\u2010s interval and tolerance to a noxious mechanical stimulus. Inflammation\u2010related variables measured were skin temperature, limb circumference, body temperature, plasma haptoglobin concentration and peripheral blood leucocyte parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Meloxicam was effective in improving all pain\u2010related variables. A dose\u2010dependent response was seen between 0 and 1.0 mg\/kg, with no additional benefit provided by 1.5 mg\/kg. At a dose rate of 1.0 mg\/kg, meloxicam improved weight borne on the turpentine\u2010treated limb by 14%, reduced the time the treated limb was held in a non\u2010weight\u2010bearing posture by 46%, reduced the lameness score by 58% and improved tolerance to pressure by 52%. No significant effects of meloxicam on inflammatory variables or appetite were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Using a validated pain model, the data suggested that 1.0 mg\/kg meloxicam provided significant analgesic benefits to sheep.<\/jats:p><\/jats:sec>","DOI":"10.1111\/avj.12779","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T05:01:23Z","timestamp":1548738083000},"page":"23-32","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Efficacy of meloxicam in a pain model in sheep"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9497-5148","authenticated-orcid":false,"given":"IG","family":"Colditz","sequence":"first","affiliation":[{"name":"CSIRO FD McMaster Laboratory Locked Bag 1, Delivery Centre, Armidale New South Wales 2350 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DR","family":"Paull","sequence":"additional","affiliation":[{"name":"CSIRO FD McMaster Laboratory Locked Bag 1, Delivery Centre, Armidale New South Wales 2350 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JB","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Joan Lloyd Consulting Pty Ltd West Ryde, NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Johnston","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Animal Health Pty Ltd Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AH","family":"Small","sequence":"additional","affiliation":[{"name":"CSIRO FD McMaster Laboratory Locked Bag 1, Delivery Centre, Armidale New South Wales 2350 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2000.36156"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2007.00114.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smallrumres.2005.07.028"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2011.00809.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2007.01.020"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706372"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2010.01195.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2009.00429.x"},{"key":"e_1_2_8_10_1","volume-title":"Policy on pain and analgesia","author":"Australian Veterinary Association","year":"2014"},{"key":"e_1_2_8_11_1","unstructured":"Animal Health Australia.Australian animal welfare standards and guidelines: sheep. 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