{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:31:57Z","timestamp":1759336317645},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Intoxication following ingestion of the popular garden shrub \u2018Yesterday, today, tomorrow\u2019 (<jats:italic>Brunfelsia<\/jats:italic> sp.) is known to result in gastrointestinal and central nervous system clinical signs in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>A 2\u2010year\u2010old dog developed acute\u2010onset vomiting, profuse diarrhoea and ptyalism after unsupervised access to an enclosed backyard that contained a <jats:italic>Brunfelsia<\/jats:italic> sp. shrub. During initial assessment the watery diarrhoea contained plant material and the dog appeared painful on abdominal palpation. Soon after admission, severe neurological abnormalities developed. Decontamination was undertaken by gastric and colonic lavage under general anaesthesia, but on recovery the patient had generalised seizures that were unresponsive to benzodiazepines. Following treatment with multiple antiepileptic medications and endotracheal intubation for loss of gag reflex, the patient developed respiratory failure requiring mechanical ventilation. Four days after initial presentation, the patient developed cardiac dysrhythmia leading to fatal cardiac arrest. Plant material recovered from the shrub and the patient\u2019s gastrointestinal tract were identified as <jats:italic>Brunfelsia<\/jats:italic> spp.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first report of hypoventilation, severe cardiac dysrhythmia and cardiac arrest associated with <jats:italic>Brunfelsia<\/jats:italic> sp. intoxication in a dog. Previous reports described clinical signs of gastrointestinal disease and mild cardiac dysrhythmia progressing to seizure activity and opisthotonus. Electrocardiography should form part of patient monitoring and mechanical ventilation considered for patients that develop respiratory failure, especially if massive ingestion is suspected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/avj.12815","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T17:00:17Z","timestamp":1559062817000},"page":"202-207","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hypoventilation, cardiac dysrhythmia, and cardiac arrest following acute <i>Brunfelsia<\/i> species (Yesterday, today, tomorrow) intoxication in a dog"],"prefix":"10.1111","volume":"97","author":[{"given":"JD","family":"Crowley","sequence":"first","affiliation":[{"name":"University Veterinary Teaching Hospital Sydney, Sydney School of Veterinary Science, Faculty of Science University of Sydney, Evelyn Williams Building B10  New South Wales, 2006 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KA","family":"Thomas","sequence":"additional","affiliation":[{"name":"University Veterinary Teaching Hospital Sydney, Sydney School of Veterinary Science, Faculty of Science University of Sydney, Evelyn Williams Building B10  New South Wales, 2006 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SL","family":"Donahoe","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Diagnostic Services, Sydney School of Veterinary Science, Faculty of Science University of Sydney  NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Child","sequence":"additional","affiliation":[{"name":"University Veterinary Teaching Hospital Sydney, Sydney School of Veterinary Science, Faculty of Science University of Sydney, Evelyn Williams Building B10  New South Wales, 2006 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MC","family":"Hickey","sequence":"additional","affiliation":[{"name":"University Veterinary Teaching Hospital Sydney, Sydney School of Veterinary Science, Faculty of Science University of Sydney, Evelyn Williams Building B10  New South Wales, 2006 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ET","family":"Mooney","sequence":"additional","affiliation":[{"name":"University Veterinary Teaching Hospital Sydney, Sydney School of Veterinary Science, Faculty of Science University of Sydney, Evelyn Williams Building B10  New South Wales, 2006 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1992.tb07522.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1985.tb14249.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2005.00151.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4102\/jsava.v80i2.173"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2008.00286.x"},{"key":"e_1_2_8_7_1","first-page":"551","volume-title":"Australia\u2019s poisonous plants, fungi and cyanobacteria; A guide to the species of medical and veterinary importance","author":"Mackenzie R","year":"2012"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1983.tb02854.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063879000200102"},{"key":"e_1_2_8_10_1","first-page":"51","article-title":"Poisoning with Brunfelsia australis in dogs: confirmation by the identification of plant material in biological samples","volume":"27","author":"Zeinsteger P","year":"2016","journal-title":"Rev Vet"},{"key":"e_1_2_8_11_1","first-page":"496","article-title":"Brunfelsia pauciflora\n                   (\u2018Yesterday, To\u2010Day and Tomorrow\u2019) poisoning in a dog","volume":"31","author":"Banton M","year":"1989","journal-title":"Vet Hum Toxicol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-5725"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1975.tb06950.x"},{"key":"e_1_2_8_14_1","first-page":"138","article-title":"Brunfelsia species: beautiful but deadly","volume":"103","author":"Khan SA","year":"2008","journal-title":"Vet Med"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)98119-X"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.07.029"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/59.12.1497"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1970.tb08544.x"},{"key":"e_1_2_8_19_1","first-page":"29","article-title":"Sympathetic cardiovascular effects of experimental strychnine poisoning in dogs","volume":"196","author":"Sofola OA","year":"1976","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_8_20_1","first-page":"104","volume-title":"Plumb\u2019s veterinary drug handbook","author":"Plumb D.","year":"2017"}],"container-title":["Australian Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/avj.12815","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/avj.12815","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/avj.12815","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T14:50:34Z","timestamp":1694357434000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/avj.12815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,28]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/avj.12815"],"URL":"https:\/\/doi.org\/10.1111\/avj.12815","archive":["Portico"],"relation":{},"ISSN":["0005-0423","1751-0813"],"issn-type":[{"value":"0005-0423","type":"print"},{"value":"1751-0813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,28]]},"assertion":[{"value":"2018-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}