{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T20:31:59Z","timestamp":1793478719016,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>Haemorrhagic enteritis virus (HEV) causes clinical haemorrhagic enteritis in young poults and\/or subclinical immunosuppression which is often associated with colibacillosis. This disease is controlled with live vaccines worldwide, however, importation of HEV vaccines or cells that support HEV propagation are not permitted in Australia. A major experiment in isolators was conducted to test the safety and efficacy of a putative HEV vaccine. The study had a factorial design with four factors namely vaccination age (28 and 42\u2009days of age), vaccine dose (0, 10<jats:sup>5<\/jats:sup>, 10<jats:sup>6<\/jats:sup>, 10<jats:sup>7<\/jats:sup> genomic copies of HEV vaccine), challenge with HEV (yes, no) and vaccination\u2010challenge interval (7, 21 or 42\u2009days). A total of 315 poults were used providing 6\u20108 birds per treatment combination. Turkey growth rate, mortality, pathological findings, anti\u2010HEV antibodies and viral load were examined. Vaccination lead to significant increases in anti HEV antibody over the following 2\u20104\u2009weeks. Overall, vaccination with 10<jats:sup>6<\/jats:sup> and 10<jats:sup>7<\/jats:sup> was protective against increase in relative splenic weight and splenic viral load in challenged birds. Clinical haemorrhagic enteritis was not induced by any treatment but there was an increased incidence of airsacculitis in groups receiving either HEV vaccine or challenge virus compared to the negative control birds (25.8\u201029.3% vs. 9.4%, P\u2009&lt;\u20090.05). Growth rate, mortality and relative bursal weight were unaffected by vaccination. This laboratory level study indicates that the putative vaccine is safe and likely to be efficacious, but may cause elevated levels of airsacculitis. These findings require confirmation in larger scale field trials.<\/jats:p>","DOI":"10.1111\/avj.12841","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T07:45:35Z","timestamp":1563781535000},"page":"323-332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Preliminary testing in turkeys of the safety and efficacy of a putative haemorrhagic enteritis virus vaccine"],"prefix":"10.1111","volume":"97","author":[{"given":"Phuong","family":"Hoang","sequence":"first","affiliation":[{"name":"Animal Science, School of Environmental and Rural Science University of New England  Armidale NSW 2351 Australia"},{"name":"Faculty of \u2018Chan Nuoi Thu Y\u2019 Tay Nguyen University, 567 Le Duan Street  Buon Ma Thuot City DakLak Province Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla F.","family":"Gerber","sequence":"additional","affiliation":[{"name":"Animal Science, School of Environmental and Rural Science University of New England  Armidale NSW 2351 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Animal Science, School of Environmental and Rural Science University of New England  Armidale NSW 2351 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"McMillan","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Biology, School of Science and Technology University of New England  Armidale NSW 2351 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Gray","sequence":"additional","affiliation":[{"name":"Inghams Enterprises P\/L  Morrisset NSW 2264"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen W.","family":"Walkden\u2010Brown","sequence":"additional","affiliation":[{"name":"Animal Science, School of Environmental and Rural Science University of New England  Armidale NSW 2351 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,22]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"276","volume-title":"Diseases of Poultry","author":"Pierson F.W.","year":"2003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801238-3.02523-X"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2307\/1590676"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2307\/1589414"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2307\/1589578"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2307\/1589513"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1981.tb05854.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1990.tb03034.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","unstructured":"Gerber P.F. Hossain M.F. Reynolds P. Hoang P. Burgess S.K. Renz K. McMillan M. Katz M.E. andWalkden\u2010Brown S.W.(2017). Propagation of an avirulent turkey haemorrhagic enteritis virus isolate in chickens. Avian Diseases 0 null.","DOI":"10.1637\/11762-102317-Reg.1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1988.tb14434.x"},{"key":"e_1_2_9_12_1","unstructured":"Walkden\u2010Brown S. Katz M. Mcmillan M. Hossain F. Renz K. Gerber P. Gray P. andAlfirevich S.(2017). Vaccine and Diagnostics for Haemorrhagic Enteritis of Turkeys. In. (Armidale Final Report of Project 1.1.9. Poultry CRC)."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1637\/10384-092412-ResNote.1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2307\/1591160"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2307\/1590141"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/1589892"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2016.11.002"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2427(94)05323-K"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1637\/8575-010509-Reg.1"}],"container-title":["Australian Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/avj.12841","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/avj.12841","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/avj.12841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T18:11:07Z","timestamp":1694283067000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/avj.12841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,22]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/avj.12841"],"URL":"https:\/\/doi.org\/10.1111\/avj.12841","archive":["Portico"],"relation":{},"ISSN":["0005-0423","1751-0813"],"issn-type":[{"value":"0005-0423","type":"print"},{"value":"1751-0813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,22]]},"assertion":[{"value":"2018-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}