{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:45:14Z","timestamp":1747183514567,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T00:00:00Z","timestamp":1568678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"APIAM Animal Health"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Swine dysentery (SD) caused by <jats:italic>Brachyspira hyodysenteriae<\/jats:italic> is an important disease in Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study is to evaluate the macrolide antibiotic kitasamycin for use in SD control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The minimum inhibitory concentrations (MICs) of kitasamycin, tylosin and lincomycin for 32 Australian isolates of <jats:italic>B. hyodysenteriae<\/jats:italic> were evaluated. Mutations in the 23S rRNA gene were examined. Isolate \u201813\u2019 with a low kitasamycin MIC was used to challenge weaner pigs. Sixty pigs were housed in 20 pens each containing three pigs: pigs in four pens received 2\u2009kg\/tonne of a product containing kitasamycin (3.1% active) prophylactically in their food starting 4\u2009days before <jats:italic>B. hyodysenteriae<\/jats:italic> challenge (group 1); pigs in four pens were challenged and received the same dose therapeutically once one pig in a pen showed diarrhoea (group 2); four pens were challenged and received 4\u2009kg\/tonne of the product therapeutically (group 3); four pens were challenged but not medicated (group 4); two pens were unmedicated and unchallenged (group 5) and two pens received 2\u2009kg\/tonne and were unchallenged (group 6). Pigs were monitored for <jats:italic>B. hyodysenteriae<\/jats:italic> excretion and disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Macrolide resistance was widespread, and mutations in the 23S rRNA gene were identified in 23 isolates. Four isolates with kitasamycin MICs\u2009&lt;\u20095\u2009\u03bcg\/mL were considered susceptible. Following experimental challenge, 10 of 12 unmedicated pigs developed SD. No pigs receiving kitasamycin prophylactical or therapeutically developed SD. Medicated pigs shed low numbers of <jats:italic>B. hyodysenteriae<\/jats:italic> in their faeces.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Kitasamycin can help control SD in pigs infected with susceptible isolates of <jats:italic>B. hyodysenteriae<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/avj.12876","type":"journal-article","created":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T07:31:24Z","timestamp":1568705484000},"page":"452-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Testing the efficacy of kitasamycin for use in the control and treatment of swine dysentery in experimentally infected pigs"],"prefix":"10.1111","volume":"97","author":[{"given":"T","family":"La","sequence":"first","affiliation":[{"name":"School of Veterinary and Life Sciences Murdoch University  Murdoch Western Australia 6150 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