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Controls (n = 851) received the OV program: day 0 gonadotropin\u2010releasing hormone, day 7 prostaglandin F<jats:sub>2\u03b1<\/jats:sub> (PGF), day 9 gonadotropin\u2010releasing hormone and FTAI at day 10. The treatment group (n = 852) received a MO program with an additional prostaglandin injection on day 8. Subsets of cows from each group were sampled for blood progesterone at the time of FTAI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The treatment group demonstrated FTAI conception rates that were 7% (95% confidence interval 2%\u201312%) greater than the control group. After adjusting for the effect of age, days in milk at Mating Start Date and herd, the odds of conception using FTAI was 1.36 (95% confidence interval 1.12\u20131.66) times greater for treatment group cows compared with control group cows. The variability of serum progesterone concentrations at the time of FTAI was significantly less for treatment group cows compared with control group cows.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For Holstein\u2010Friesian and Holstein\u2010Friesian cross\u2010bred cows managed in pasture\u2010based dairy herds in southern Australia, a MO protocol, including a second injection of prostaglandin F<jats:sub>2\u03b1<\/jats:sub> on day 8, increased FTAI conception rates compared with cows receiving the OV protocol.<\/jats:p><\/jats:sec>","DOI":"10.1111\/avj.12918","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T06:45:04Z","timestamp":1584600304000},"page":"190-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of a second treatment of prostaglandin F<sub>2\u03b1<\/sub> during the Ovsynch program on fixed\u2010time artificial insemination conception rates and luteolysis in split\u2010calving, pasture\u2010fed dairy cows"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2754-7108","authenticated-orcid":false,"given":"JM","family":"Rheinberger","sequence":"first","affiliation":[{"name":"Faculty of Veterinary and Agricultural Sciences The University of Melbourne  Werribee Victoria 3030 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DD","family":"Colson","sequence":"additional","affiliation":[{"name":"The Vet Group  Allansford Victoria 3280 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5519-9123","authenticated-orcid":false,"given":"DS","family":"Beggs","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary and Agricultural Sciences The University of Melbourne  Werribee Victoria 3030 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PD","family":"Mansell","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary and Agricultural Sciences The University of Melbourne  Werribee Victoria 3030 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MA","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary and Agricultural Sciences The University of Melbourne  Werribee Victoria 3030 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RJ","family":"Rheinberger","sequence":"additional","affiliation":[{"name":"Ironmines Veterinary Clinic  Mittagong New South Wales 2575 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MF","family":"Pyman","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary and Agricultural Sciences The University of Melbourne  Werribee Victoria 3030 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2015-9353"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2003.tb13369.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2005.10.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2005.10.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(97)75937-X"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2008-1289"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4320(02)00087-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2005.tb11588.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2015-9719"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(89)79081-0"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2003.tb11552.x"},{"key":"e_1_2_9_13_1","unstructured":"Siemens Healthcare Diagnostics. 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