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Prothrombin time was rechecked 1 h after treatment in the remaining three dogs and all results were within the normal reference range. All four dogs were discharged from hospital within 48\u2009h of presentation. Intravenous vitamin K<jats:sub>1<\/jats:sub> rapidly reverses the coagulopathic state in dogs with anticoagulant rodenticide toxicosis. It is a viable alternative therapy to plasma transfusion if circumstances preclude its use; however, patients must be monitored for anaphylactoid reactions.<\/jats:p>","DOI":"10.1111\/avj.12931","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T06:45:04Z","timestamp":1584600304000},"page":"225-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Intravenous vitamin K<sub>1<\/sub> normalises prothrombin time in 1 hour in dogs with anticoagulant rodenticide toxicosis"],"prefix":"10.1111","volume":"98","author":[{"given":"ET","family":"Mooney","sequence":"first","affiliation":[{"name":"Sydney School of Veterinary Science University of Sydney  New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Agostini","sequence":"additional","affiliation":[{"name":"Sydney School of Veterinary Science University of Sydney  New South Wales Australia"},{"name":"U\u2010Vet Animal Hospital Werribee, Faculty of Veterinary and Agricultural Sciences University of Melbourne  Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Griebsch","sequence":"additional","affiliation":[{"name":"Sydney School of Veterinary Science University of Sydney  New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hickey","sequence":"additional","affiliation":[{"name":"Sydney School of Veterinary Science University of Sydney  New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,18]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"BreckenridgeAM LeckJB ParkBKet al.Mechanisms of action of the anticoagulants warfarin 2\u2010chloro\u20103\u2010phytylnaphthoquinone (Cl\u2010K) acenocoumarol brodifacoum and difenacoum in the rabbit. 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