{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:30:55Z","timestamp":1758637855713,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Red Healer and Red Healer Laboratories","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the efficacy of an herbal spray combining various essential oils, with a claim of mast cell stabilisation, antipruritic, anti\u2010inflammatory, and insect repellent effects on the clinical presentation of insect bite hypersensitivity (IBH) in horses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Double\u2010blinded, placebo\u2010controlled, randomised, cross\u2010over clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty adult horses with clinical IBH were treated with a daily application of herbal spray or placebo for 28 days in a randomised, cross\u2010over fashion, separated by a&gt;28\u2010day washout period. Horses were examined and scored prior to and after the completion of each treatment. Histopathology was performed on four horses. Owners kept daily diaries of observations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The herbal spray significantly reduced the severity of all assessed parameters (pruritus, excoriations, lichenification and alopecia; P &lt; 0.05) compared with baseline values (pretreatment) and with placebo. Owners reported improvement of pruritus in 19\/20 horses (95%) with complete resolution in 17 horses (85%) following treatment. Skin biopsies showed resolution of orthokeratosis in 4\/4 horses, reduced thickness of the stratum spinosum in 2\/4 horses and complete resolution of histopathological abnormalities in 1\/4 horses after treatment, compared with either no change or deterioration of histopathologic lesions after placebo. No side effects were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The tested herbal spray may be an effective treatment for the management of equine IBH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/avj.12963","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T09:16:01Z","timestamp":1596705361000},"page":"411-416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Essential oil spray reduces clinical signs of insect bite hypersensitivity in horses"],"prefix":"10.1111","volume":"98","author":[{"given":"A","family":"Cox","sequence":"first","affiliation":[{"name":"School of Veterinary Science The University of Queensland  Gatton Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Wood","sequence":"additional","affiliation":[{"name":"School of Veterinary Science The University of Queensland  Gatton 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