{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:37:47Z","timestamp":1777610267521,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The primary aim of this study was to investigate the contraceptive efficacy of a self\u2010assembling uterine device (iUPOD\u2122) in the mare. In addition, the effects of iUPODs on oestrous cyclicity, uterine health and circulating concentrations of cortisol were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Domestic mares underwent oestrous monitoring and artificial insemination. After subsequent ovulation, mares underwent either placement (n = 7) or sham placement (n = 7; controls) of an iUPOD device. Devices were left in place for at least 3 months. Pregnancy diagnoses were carried out 14\u2009days post\u2010ovulation, with any pregnancies terminated at 28\u2009days post\u2010ovulation. All mares underwent weekly blood sampling with or without reproductive examinations throughout the study. Towards the end of the study, multiple serum samples collected over three consecutive days were analysed for concentrations of cortisol. Endometrial biopsies were collected before artificial insemination and during the subsequent breeding season. Endometrial cytology and bacterial cultures were performed before device removal (iUPOD mares) or at the end of the study (control mares).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pregnancies were diagnosed in 0 of 7 iUPOD mares versus 7 of 7 control mares. Placement of iUPODs was associated with extended luteal phases and variable accumulations of intra\u2010uterine fluid. Bacterial culture results suggested that the mild endometritis associated with iUPODs was sterile in six of seven mares. Short\u2010term placement of iUPODs had no detrimental effects on endometrial architecture. Mean serum cortisol concentrations were significantly lower in iUPOD mares than control mares.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>iUPODs represent a promising means of fertility control in the mare.<\/jats:p><\/jats:sec>","DOI":"10.1111\/avj.13055","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T06:40:34Z","timestamp":1611038434000},"page":"130-136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The contraceptive efficacy of a self\u2010assembling intra\u2010uterine device in domestic mares"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9682-8969","authenticated-orcid":false,"given":"CJ","family":"Joon\u00e8","sequence":"first","affiliation":[{"name":"College of Public Health, Medical and Veterinary Sciences James Cook University  Townsville Queensland 4811 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CM","family":"Gradil","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Animal Science University of Massachusetts  Amherst Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JA","family":"Picard","sequence":"additional","affiliation":[{"name":"College of Public Health, Medical and Veterinary Sciences James Cook University  Townsville Queensland 4811 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JD","family":"Taylor","sequence":"additional","affiliation":[{"name":"College of Public Health, Medical and Veterinary Sciences James Cook University  Townsville Queensland 4811 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"de Tonnerre","sequence":"additional","affiliation":[{"name":"College of Public Health, Medical and Veterinary Sciences James Cook University  Townsville Queensland 4811 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0618-1298","authenticated-orcid":false,"given":"J","family":"Cavalieri","sequence":"additional","affiliation":[{"name":"College of Public Health, Medical and Veterinary Sciences James Cook University  Townsville Queensland 4811 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1071\/WR06102"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1071\/WR17136"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2012.00577.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12557"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/wsb.729"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201570"},{"key":"e_1_2_8_8_1","unstructured":"United Nations Department of Economic and Social Affairs Population Division.Contraceptive Use by Method 2019: Data Booklet (ST\/ESA\/SER.A\/435) 2019. 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