{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T15:21:00Z","timestamp":1748359260533},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>5\u2010Fluorouracil (5\u2010FU) cream is a common human topical chemotherapy agent with potentially fatal neurotoxic effects on dogs if accidentally ingested. There are seldom reports in veterinary literature describing the successful outcome of intervention after accidental ingestion of 5\u2010FU cream.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Summary<\/jats:title><jats:p>A 9\u2010month\u2010old spayed female labradoodle presented 14\u2009h after ingesting an unknown amount of 40\u2009g tube of Efudex cream (5% 5\u2010FU). The dog presented in status epilepticus, which was managed with benzodiazepines and levetiracetam in conjunction with induced coma and mechanical ventilation. No further seizure activity occurred throughout the ensuing 5\u2009days of hospitalisation; however, myelosuppression was featured. The dog was discharged home after 5\u2009days of hospitalisation. Three days post discharge, the dog was noted to develop focal alopecia around the eyes and temporal region. 14\u2009days after discharge, the alopecia progressed to a majority of the head and body.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To the authors' knowledge, this is the first report that documents the enduring adverse effects of 5\u2010FU cream after survival of the initial episode, including an earlier onset of myelosuppression and diffuse alopecia. Successful treatment of accidental 5\u2010FU ingestion is possible several hours after the initial event with minimal long\u2010term consequences.<\/jats:p><\/jats:sec>","DOI":"10.1111\/avj.13154","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T05:49:21Z","timestamp":1646372961000},"page":"236-242","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transient chemotherapy\u2010induced alopecia after successful reversal of 5\u2010fluorouracil myelosuppression and neurotoxicosis in a 9\u2010month\u2010old dog"],"prefix":"10.1111","volume":"100","author":[{"given":"LM","family":"Immelman","sequence":"first","affiliation":[{"name":"Veterinary Specialist Services  Carrara Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IH","family":"Goodman","sequence":"additional","affiliation":[{"name":"Veterinary Specialist Services  Carrara Queensland 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