{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:43:10Z","timestamp":1747183390404,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>The authors report an unusual case of<jats:italic>Clostridium chauvoei<\/jats:italic>causing severe panophthalmitis in Merino lambs. More than half of the lambs affected survived, which is unusual for clostridial disease; however, there have been reports in humans that the mortality risk for ocular gas gangrene is lower than when other body parts are affected. A combination of factors in this case included environmental contamination (specific to a particular paddock), genetics predisposing to entropion (lambs born of maiden 2\u2010year\u2010old ewes with some inbreeding), the practice of manually everting eyelids for the entropion and vaccination strategies.<jats:italic>C. chauvoei<\/jats:italic>was cultured in pure growth from the eye of a lamb affected by severe panophthalmitis. Histopathology was consistent with severe acute infection, and microscopic sections showed Gram\u2010positive organisms associated with the inflammatory response in the eye. In the acutely affected animal examined there were no signs that the lesions were long\u2010standing. Animals that recovered had one or both eyes destroyed. This report describes that malignant oedema in sheep due to<jats:italic>C. chauvoei<\/jats:italic>can manifest as acute and severe panophthalmitis. The case fatality rate of lambs with panophthalmitis was less than 50%, lower than normally occurs for clostridial diseases. Clostridial vaccination of the ewes may have provided a low level of protection in reducing the case fatality rate in the affected lambs as well localisation of the infection from the blood\u2013ocular barrier.<\/jats:p>","DOI":"10.1111\/avj.13191","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T05:17:07Z","timestamp":1654579027000},"page":"459-463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clostridial panophthalmitis \u2013 An unusual case of localised malignant oedema in Merino lambs associated with<i>Clostridium chauvoei<\/i>"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4416-3579","authenticated-orcid":false,"given":"BJ","family":"Moloney","sequence":"first","affiliation":[{"name":"NSW Deparment of Primary Industries Orange Regional Veterinary Laboratory Orange New South Wales 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