{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:13:01Z","timestamp":1782227581788,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>Corneal ulceration is a common ophthalmic condition in horses. It is frequently caused by trauma to the corneal surface, followed by secondary infection by commensal or pathogenic organisms including S<jats:italic>treptococcus equi<\/jats:italic> subspecies <jats:italic>zooepidemicus<\/jats:italic>, <jats:italic>Pseudomonas aeruginosa<\/jats:italic> and <jats:italic>Staphylococcus<\/jats:italic> spp. Emerging antimicrobial resistance amongst these organisms has raised the need for appropriate antimicrobial therapy selection, to optimise treatment efficacy while minimising further antimicrobial resistance. Medical records of 38 horses presented at the University Veterinary Teaching Hospital Camden for ulcerative keratitis between 2010 and 2020 were reviewed to identify those with positive bacterial cultures and antimicrobial susceptibility profiles (13\/38). Common susceptibility patterns were identified and used to guide the empirical treatment of equine bacterial corneal ulcers. <jats:italic>Pseudomonas<\/jats:italic> spp<jats:italic>.<\/jats:italic> (64.3%), S<jats:italic>treptococcus equi<\/jats:italic> subspecies <jats:italic>zooepidemicus<\/jats:italic> (14.3%) and <jats:italic>Actinobacillus<\/jats:italic> spp<jats:italic>.<\/jats:italic> (14.3%) were most commonly identified. Susceptibility to amikacin, gentamicin and ciprofloxacin was observed in 100%, 66.7% and 85.7% <jats:italic>Pseudomonas<\/jats:italic> spp. isolates respectively. Resistance to polymyxin B and neomycin occurred in 85.7% and 71.4% of <jats:italic>Pseudomonas<\/jats:italic> spp., respectively. All S<jats:italic>treptococcus equi<\/jats:italic> subspecies <jats:italic>zooepidemicus<\/jats:italic> organisms in this study were susceptible to ceftiofur, cephalexin, penicillin and ampicillin, while they were all resistant to gentamicin, neomycin, enrofloxacin and marbofloxacin. Predominating in this study, <jats:italic>Pseudomonas<\/jats:italic> spp<jats:italic>.<\/jats:italic> maintained overall aminoglycoside susceptibility despite some emerging resistance, and good fluoroquinolone susceptibility. High resistance to Polymyxin B could have arisen from its common use as first\u2010line therapy for bacterial corneal ulcers. Although further research is required, these new findings about predominant bacteria in equine corneal ulceration in the Camden region and their antimicrobial susceptibility patterns can be used to guide the empirical treatment of bacterial corneal ulcers in horses.<\/jats:p>","DOI":"10.1111\/avj.13221","type":"journal-article","created":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T07:10:00Z","timestamp":1669446600000},"page":"115-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Susceptibility pattern of bacterial isolates in equine ulcerative keratitis: Implications for empirical treatment at a university teaching hospital in Sydney"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3528-9567","authenticated-orcid":false,"given":"M","family":"Deniaud","sequence":"first","affiliation":[{"name":"School of Veterinary Science University of Sydney  Sydney New South Wales 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