{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:24:17Z","timestamp":1780669457551,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>Malignant mesothelioma (MM) is uncommon in cats and dogs and can be challenging to diagnose. Adequate tissue sampling is required for superior diagnostic accuracy. Protoporphyrin IX, a metabolite of 5\u2010aminolaevulinic acid (5\u2010ALA), is a photosensitiser for photodynamic diagnosis (PDD). To the best of our knowledge, no study has reported the use of 5\u2010ALA\u2010PDD to detect MM in veterinary medicine. The present study describes the use of 5\u2010ALA\u2010PDD for MM diagnosis in a cat and dog, as well as the effectiveness of intracavitary chemotherapy. We evaluated the use of PDD with 5\u2010ALA hydrochloride (5\u2010ALA\u2010PDD) in two cases of MM. A 12\u2010year\u2010old cat presented with a 1\u2010month history of respiratory distress, and a 9\u2010year\u2010old dog presented with a 3\u2010month history of mild abdominal distention. We endoscopically biopsied lesions in both the cases using 5\u2010ALA\u2010PDD. Histopathological examination revealed mesothelioma, and immunohistochemical staining was positive for calretinin. Both patients were treated with carboplatin. The cat died of respiratory failure. Although, the dog's condition improved 21\u2009days after the first chemotherapeutic drug administration, the dog died on day 684 owing to cardiac\u2010related issues. 5\u2010ALA\u2010PDD is thus, safe and feasible for the diagnosis of MM in veterinary medicine.<\/jats:p>","DOI":"10.1111\/avj.13224","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T02:04:13Z","timestamp":1670551453000},"page":"99-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Utility of 5\u2010aminolaevulinic acid fluorescence\u2010guided endoscopic biopsy for malignant mesothelioma in a cat and dog"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2689-9435","authenticated-orcid":false,"given":"T","family":"Osaki","sequence":"first","affiliation":[{"name":"Joint Department of Veterinary Clinical Medicine Faculty of Agriculture, Tottori University  Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Amaha","sequence":"additional","affiliation":[{"name":"Joint Department of Veterinary Clinical Medicine Faculty of Agriculture, Tottori University  Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Murahata","sequence":"additional","affiliation":[{"name":"Joint Department of Veterinary Clinical Medicine Faculty of Agriculture, Tottori University  Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Sunden","sequence":"additional","affiliation":[{"name":"Joint Department of Veterinary Clinical Medicine Faculty of Agriculture, Tottori University  Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Iguchi","sequence":"additional","affiliation":[{"name":"Joint Department of Veterinary Clinical Medicine Faculty of Agriculture, Tottori University  Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Harada","sequence":"additional","affiliation":[{"name":"Joint Department of Veterinary Clinical Medicine Faculty of Agriculture, Tottori University  Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Tsujino","sequence":"additional","affiliation":[{"name":"Joint Department of Veterinary Clinical Medicine Faculty of Agriculture, Tottori University  Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Murakami","sequence":"additional","affiliation":[{"name":"SBI Pharmaceuticals Co., Ltd.  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