{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T06:45:38Z","timestamp":1775976338223,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T00:00:00Z","timestamp":1681603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>There is a need for a safe, effective and practical method of oestrus suppression in the mare. The aim of this study was to monitor ovarian activity in mares exposed to either 9.4 or 28.2\u2009mg deslorelin acetate, a GnRH agonist, in the form of a sustained\u2010release implant. Following oestrus synchronisation, mares were randomly assigned to one of three groups (<jats:italic>n<\/jats:italic>\u2009=\u20094 per group) and administered either one (Des1 group; 9.4\u2009mg) or three (Des3 group; 28.2\u2009mg) implants of deslorelin acetate (Suprelorin\u201012, Virbac Australia) or one blank implant (Control group; Virbac Australia). Mares underwent weekly blood sampling for 12\u2009weeks following implant placement (Day 0\u2013Day 84), with transrectal palpation and ultrasonography of the reproductive tract at all sampling timepoints except Days 56, 70 and 77. All mares showed baseline serum progesterone concentrations (SPC; \u22641.3\u2009nmol\/L or 0.4\u2009ng\/ml) on Day 0. Cycling Control mares showed typical oestrous cyclicity characterised by peaks and troughs in SPC over time. Four of eight treated mares demonstrated a sustained elevation in SPC after the initial ovulation after implant placement; SPC declined to baseline levels (Des1 group; 2 mares) or remained elevated (Des3 group; 2 mares) at the final sampling timepoint on Day 84. Oestrous cyclicity was erratic in three of the remaining four treated mares. In total, 87.5% (7 of 8) of treated mares showed atypical oestrous cyclicity after implant placement. These results suggest that deslorelin acetate disrupts oestrous cyclicity in the mare, which warrants further research.<\/jats:p>","DOI":"10.1111\/avj.13244","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T04:53:28Z","timestamp":1681707208000},"page":"275-278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sustained\u2010release deslorelin acetate implants disrupt oestrous cyclicity in the mare"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9682-8969","authenticated-orcid":false,"given":"CJ","family":"Joon\u00e8","sequence":"first","affiliation":[{"name":"College of Public Health, Medical and Veterinary Sciences James Cook University Townsville Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0618-1298","authenticated-orcid":false,"given":"J","family":"Cavalieri","sequence":"additional","affiliation":[{"name":"College of Public Health, Medical and Veterinary Sciences James Cook University Townsville Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,16]]},"reference":[{"key":"e_1_2_4_2_1","unstructured":"U.S. Food and Drug Administration.FDA Animal Drug Safety Communication: FDA highlights potential health risks to people exposed to altrenogest products for horses or pigs. 2018.https:\/\/www.fda.gov\/animal-veterinary\/cvm-updates\/fda-animal-drug-safety-communication-fda-highlights-potential-health-risks-people-exposed."},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/eve.13405"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2004.04.009"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.domaniend.2020.106505"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11061600"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093-691X(90)90049-Y"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jveb.2013.02.001"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2018.05.027"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4320(95)01383-B"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0737-0806(00)80381-0"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0737-0806(01)70158-X"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(02)00912-3"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.218.749"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ansci\/80.10.2681"},{"key":"e_1_2_4_16_1","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.2460\/ajvr.1993.54.10.1746","article-title":"Effect of constant administration of a gonadotropin\u2010releasing hormone agonist on reproductive activity in mares: preliminary evidence on suppression of ovulation during the breeding season","volume":"54","author":"Fitzgerald B","year":"1993","journal-title":"Am J Vet Res"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2015.03.015"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2009.04.012"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0737-0806(07)80266-8"}],"container-title":["Australian Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/avj.13244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T10:52:09Z","timestamp":1729248729000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/avj.13244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,16]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/avj.13244"],"URL":"https:\/\/doi.org\/10.1111\/avj.13244","archive":["Portico"],"relation":{},"ISSN":["0005-0423","1751-0813"],"issn-type":[{"value":"0005-0423","type":"print"},{"value":"1751-0813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,16]]},"assertion":[{"value":"2023-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}