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The objective of this study was to determine the changes, if any, to levels of endotoxin in cattle plasma in response to early\u2010stage infection with <jats:italic>Fasciola hepatica<\/jats:italic>. Thirty\u2010six (36) commercial bred cattle were experimentally infected with approximately 400 viable metacercariae. Plasma lipopolysaccharide (endotoxin) levels were examined on 24 occasions from 0\u2009h before infection to 336\u2009h after infection using the Limulus Amoebocyte Lysate chromogenic end point assay and compared with that of six (6) uninfected control animals. Peak lipopolysaccharide levels in infected animals were reached at 52\u2009h after infection and returned to pre\u2010infection levels at time 144\u2009h after infection. Infected animals had significantly elevated lipopolysaccharide levels between 24 and 120\u2009h after infection when compared to uninfected animals. The mean change in endotoxin units (EU)\/mL over time after infection was statistically significant in infected animals. 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