{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:56Z","timestamp":1787013896559,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2023,10]]},"abstract":"\n Background<\/jats:title>\n \n Cryptococcus is one of the most common systemic mycosis worldwide, infecting young adults of the large to giant breed dogs. Infection is commonly acquired from the environment via the sinonasal cavity as the main portal of entry. It either remains there, or spreads to the central nervous system (CNS) and the eye (optic nerve and retina) by penetration of the cribriform plate, or haematogenously to other viscera. Lung involvement is uncommon in cats and dogs in contrast to human and equine patients. Whilst there is a wide genetic diversity amongst\n Cryptococcus neoformans<\/jats:italic>\n and\n Cryptococcus gattii<\/jats:italic>\n isolates along the West Coast and Northern parts of Australia, the molecular diversity of\n C.\u2009gatti<\/jats:italic>\n is considered very low on the East Coast of Australia, with a huge preponderance of VGI cases. We report on a young small breed brachycephalic dog that presented with extreme gastrointestinal and respiratory signs, but no CNS involvement. It is the first reported case of\n C.\u2009gattii<\/jats:italic>\n VGII genotype in a companion animal from Queensland.\n <\/jats:p>\n <\/jats:sec>\n \n Case Report<\/jats:title>\n \n A 9\u2010month old female entire French Bulldog presented initially for diarrhoea. Clinical progression was accompanied by the development of respiratory signs, so the patient was referred to a 24\u2009h care facility. Following hospitalisation, the patient became hypoxemic requiring mechanical ventilation. A bronchoalveolar lavage performed antemortem confirmed abundant\n Cryptococcal<\/jats:italic>\n spp. Further culturing and genotyping identified the species as\n Cryptococcus gattii<\/jats:italic>\n VGII. Post\u2010mortem findings indicated gross gastrointestinal and mesenteric involvement, with possible dissemination to the local mesenteric lymph node and lungs.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This case describes a rare example of a\n Cryptococcus spp<\/jats:italic>\n suspected of disseminating from the gastrointestinal tract to the lungs, without involvement of the CNS. The observation of this finding in a small brachycephalic breed is unusual, and the finding of genotype VGII on the East Coast of Queensland is extremely unusual as there is no prior travel history of the dog or owners. The presence of a miliary lung pattern with primary gastrointestinal disease in a small breed dog warrants adding cryptococcosis to the differential diagnosis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/avj.13273","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T01:04:46Z","timestamp":1691111086000},"page":"377-382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A severe case of disseminated cryptococcosis in a young French bulldog living in South\u2010East Queensland caused by\n Cryptococcus gattii<\/i>\n VGII"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9614-9257","authenticated-orcid":false,"given":"C","family":"Reddrop","sequence":"first","affiliation":[{"name":"Animal Emergency Service Carrara Queensland 4211 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