{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T22:29:06Z","timestamp":1781562546092,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>Although cryptococcosis is the most common systemic fungal disease of cats, abdominal involvement is rarely reported. The pathogenesis of cryptococcosis usually involves sinonasal colonisation, followed by tissue invasion and sinonasal infection, with possible subsequent spread to the lungs and\/or direct extension into the central nervous system (CNS), for example, via the cribriform plate. Further haematogenous spread can occur to any tissue, including skin and the CNS. This report describes a case of disseminated cryptococcosis due to <jats:italic>Cryptococcus neoformans<\/jats:italic> species complex in a 13\u2010year\u2010old cat, the fourth documented Australian feline case with abdominal involvement. The cat presented with a chronic history of upper respiratory disease that progressed to severe lethargy and anorexia. An autopsy revealed striking peritonitis with multifocal abdominal involvement affecting the liver, spleen, adrenal glands, kidneys, pancreas and mesentery. Cryptococcal organisms were also observed in organs within the thoracic cavity, sinonasal tissues and the CNS. Testing of abdominal fluid and serum for cryptococcal antigen using a commercially available lateral flow assay using neat fluid specimen initially tested false\u2010negative. However, after dilution of the sample to 1:64, a positive result was obtained, confirming a postzone phenomenon. Taken together, the collective findings were indicative of widely disseminated cryptococcosis due to <jats:italic>Cryptococcus neoformans<\/jats:italic> with atypical involvement of the abdominal cavity.<\/jats:p>","DOI":"10.1111\/avj.13329","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T10:05:33Z","timestamp":1712138733000},"page":"306-312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A case of disseminated cryptococcosis with abdominal involvement due to <i>Cryptococcus neoformans<\/i> species complex in a Ragdoll cat and false\u2010negative cryptococcal antigen lateral flow tests due to the postzone phenomenon"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7605-6540","authenticated-orcid":false,"given":"A","family":"Teh","sequence":"first","affiliation":[{"name":"Sydney School of Veterinary Science The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Pritchard","sequence":"additional","affiliation":[{"name":"Animal Referral Hospital  Homebush West New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SL","family":"Donahoe","sequence":"additional","affiliation":[{"name":"Sydney School of Veterinary Science The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6025-194X","authenticated-orcid":false,"given":"R","family":"Malik","sequence":"additional","affiliation":[{"name":"Centre for Veterinary Education The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Krockenberger","sequence":"additional","affiliation":[{"name":"Sydney School of Veterinary Science The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13489224"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(00)05005-1"},{"key":"e_1_2_7_4_1","first-page":"7","article-title":"Cryptococcus in wildlife and free\u2010living mammals","volume":"7","author":"Danesi P","year":"2021","journal-title":"J Fungi (Basel)"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780310001624547"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802512519"},{"key":"e_1_2_7_7_1","volume-title":"Jubb, Kennedy, and Palmer's pathology of domestic animals","author":"Maxie MG","year":"2016"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.13232"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2010.00281.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2018.1431087"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19084603"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2478\/v10020-008-0041-z"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myz010"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/9781119317005.app1","volume-title":"Appendix 1: Normal organ weights (percentage body weight). Necropsy guide for dogs, cats, and small mammals","author":"McDonough SP","year":"2017"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","unstructured":"MalikR KrockenbergerMB O'BrienCRet al.Veterinary insights into cryptococcosis caused by Cryptococcus neoformans and Cryptococcus gattii. In: Heitman J Kozel TR Kwon\u2010Chung KJ Perfect JR Casadevall A editors.Cryptococcus:From human pathogen to novel yeast. 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