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A large, friable, sublingual mass was surgically resected from the oral cavity of a pink\u2010tongued skink (<jats:italic>Cyclodomorphus gerarrdii<\/jats:italic>). Histopathology, fungal culture and PCR testing with Sanger sequencing confirmed granulomatous inflammation containing large numbers of yeasts identified as <jats:italic>Cryptococcus neoformans<\/jats:italic> var. <jats:italic>grubii<\/jats:italic>. Surgical excision and treatment with oral amphotericin B and terbinafine was unsuccessful in managing the infection. On Day 67 after surgery, <jats:italic>Cryptococcus<\/jats:italic> DNA was detected by PCR in the blood but not oral, cloacal or skin swabs. The skink was euthanised 72\u2009days after surgery due to anorexia, weight loss and progressive neurological signs of disease. Necropsy results showed disseminated cryptococcosis, including meningoencephalitis and ventriculitis. Two in\u2010contact pink\u2010tongued skinks remained asymptomatic and PCR\u2010negative during 198\u2009days of observation. This case suggests <jats:italic>Cryptococcus<\/jats:italic> infections should be considered for oral masses presenting with or without neurological signs in skinks. Further investigation is required to determine the best treatment options for disseminated cryptococcosis in reptiles. This report describes the third reported case of <jats:italic>Cryptococcus<\/jats:italic> in a reptile and the first case of cryptococcosis in a pink\u2010tongued skink. It is also the first report of <jats:italic>Cryptococcus<\/jats:italic> in a reptile identified to the variety level using PCR, including in whole blood samples.<\/jats:p>","DOI":"10.1111\/avj.13337","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T01:10:40Z","timestamp":1713921040000},"page":"416-422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Diagnosis and management of <i>Cryptococcus neoformans<\/i> var. <i>grubii<\/i> detected in an oral mass in a pink\u2010tongued skink (<i>Cyclodomorphus gerarrdii<\/i>)"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6880-1096","authenticated-orcid":false,"given":"J","family":"Llinas","sequence":"first","affiliation":[{"name":"The Unusual Pet Vets Jindalee  Jindalee Queensland 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