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Thirty calves were infected with <jats:italic>Theileria orientalis<\/jats:italic> Ikeda genotype through the application and retention of infected female bush ticks (<jats:italic>Haemaphysalis longicornis<\/jats:italic>). 15 Group 1 calves were treated with a single, oral dose of toltrazuril at the dose registered in Australia for coccidiosis (15\u2009mg\/kg), concurrently with tick infection, and 15 Group 2 (control group) calves were untreated. There were no significant differences (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05) in mean parasitaemia, packed cell volume (PCV) or bodyweight between the toltrazuril treated and untreated groups at any timepoint up to Day 64 after infection, apart from a higher mean PCV for the toltrazuril treated group at Day 20. 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