{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T16:21:16Z","timestamp":1754151676037,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T00:00:00Z","timestamp":1737849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2025,5]]},"abstract":"Objectives<\/jats:title>To identify if chemotherapeutic drugs in the CHOP\u2010based protocol led to an increase in renal parameters in dogs with lymphoma during therapy and investigate whether factors such as prednisolone use or age affected this result.<\/jats:p><\/jats:sec>Methods<\/jats:title>Data were obtained retrospectively from private referral practice records of dogs diagnosed with lymphoma receiving a CHOP\u2010based chemotherapy protocol between 2015 and 2019. Dogs included received a CHOP\u2010based protocol as their first treatment, received four full cycles and were in remission at the end of the protocol. Blood samples obtained at baseline and at the time of final chemotherapy administration were analysed for serum biochemistry and haematology including creatinine, urea, phosphate, sodium, potassium, calcium, albumin, total protein, haematocrit, neutrophil and platelet count. Data were analysed using paired t<\/jats:italic>\u2010tests. Changes in the same measures were investigated for possible age effects using Pearson correlations. Changes in these measures were compared between dogs receiving or not receiving prednisolone using 2\u2010sample t\u2010tests without the assumption of equal variances. Changes were jointly compared to both age and prednisolone use in general linear models. Significance was taken as P<\/jats:italic>\u2009<\u20090.05.<\/jats:p><\/jats:sec>Results<\/jats:title>Thirty dogs met the inclusion criteria. No significant changes in serum creatinine concentrations were observed. Increased serum albumin concentration at the end of treatment was observed in younger dogs not receiving prednisolone.<\/jats:p><\/jats:sec>Impact\/Clinical significance<\/jats:title>Short\u2010term changes in renal parameters following a CHOP\u2010based chemotherapy protocol in dogs were not observed. Further prospective studies are warranted.<\/jats:p><\/jats:sec>Declaration of interest<\/jats:title>No funding was received and no conflict of interest to declare.<\/jats:p><\/jats:sec>","DOI":"10.1111\/avj.13419","type":"journal-article","created":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T22:19:49Z","timestamp":1737929989000},"page":"240-245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Short\u2010term evaluation of renal biochemical parameters in dogs completing chemotherapy for lymphoma"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7233-563X","authenticated-orcid":false,"given":"L","family":"Venman","sequence":"first","affiliation":[{"name":"North Shore Veterinary Specialist & Emergency Centre Artarmon New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Sparks","sequence":"additional","affiliation":[{"name":"Waltham Petcare Science Institute Leicestershire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3609-3830","authenticated-orcid":false,"given":"A","family":"Swallow","sequence":"additional","affiliation":[{"name":"North Shore Veterinary Specialist & Emergency Centre Artarmon New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0133.x"},{"key":"e_1_2_9_3_1","first-page":"688","volume-title":"Withrow and MacEwen's small animal clinical oncology","author":"Vail DM","year":"2020"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12378"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12364"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2010.00230.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12677"},{"key":"e_1_2_9_8_1","unstructured":"Society IRI.IRIS Staging of CKD. 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