{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:59:15Z","timestamp":1778741955974,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>Early\u2010onset muscle weakness syndrome (MW) is a recessive genetic disorder known to affect Holstein cattle. This report describes the clinical findings in an Australian Holstein calf diagnosed with MW. The calf initially presented for examination at a dairy farm at 3\u2009days of age, being recumbent since birth but able to stand with assistance. A presumptive diagnosis of traumatic injury was made at first. However, the calf was re\u2010examined multiple times due to ongoing intermittent episodes of recumbency, prompting further diagnostic investigation. Given the non\u2010specific nature of the clinical and laboratory findings, a presumptive diagnosis of MW was made after reviewing the calf's breeding pedigree. A definitive diagnosis, however, required genotype testing. To the authors knowledge, this case report represents the first peer\u2010reviewed manuscript to describe the clinical presentation of MW in an Australian Holstein calf.<\/jats:p>","DOI":"10.1111\/avj.13431","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T16:58:40Z","timestamp":1741712320000},"page":"298-303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Early\u2010onset muscle weakness syndrome (<scp>MW<\/scp>) in an Australian Holstein calf"],"prefix":"10.1111","volume":"103","author":[{"given":"MG","family":"Ciacia","sequence":"first","affiliation":[{"name":"School of Agricultural, Environmental and Veterinary Sciences, Faculty of Science and Health Charles Sturt University  Wagga Wagga New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3029-177X","authenticated-orcid":false,"given":"AJ","family":"Phipps","sequence":"additional","affiliation":[{"name":"Rochester Veterinary Practice  Rochester Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2019-17753"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3168\/jdsc.2022-0224"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2023-24121"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2008.059766"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/JND-190383"},{"key":"e_1_2_9_7_1","first-page":"675","volume-title":"Diseases of cattle in Australasia","author":"Parkinson T","year":"2019"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2016-11118"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2006.10.017"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638714546490"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.7248"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2018.01.002"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.920390"},{"key":"e_1_2_9_14_1","volume-title":"Bye muscle weakness syndrome (MW) and JH1","author":"Good RB","year":"2024"},{"key":"e_1_2_9_15_1","unstructured":"Genetics Australia. Early Onset Muscle Weakness Syndrome (MW).2023. Available at:https:\/\/genaust.com.au\/wp-content\/uploads\/GA_Holstein_Calf-Recumbency_Testing_04122023.pdf. Accessed 7 December 2024."}],"container-title":["Australian Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/avj.13431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T02:35:40Z","timestamp":1752978940000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/avj.13431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,4]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/avj.13431"],"URL":"https:\/\/doi.org\/10.1111\/avj.13431","archive":["Portico"],"relation":{},"ISSN":["0005-0423","1751-0813"],"issn-type":[{"value":"0005-0423","type":"print"},{"value":"1751-0813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,4]]},"assertion":[{"value":"2024-12-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}