{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:55:32Z","timestamp":1791968132790,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"abstract":"\n Background<\/jats:title>\n Mediastinal lymphoma in feline leukaemia virus (FeLV)\u2010positive cats is associated with a poor prognosis, and therapeutic options may be limited when adequate disease control is not achieved with chemotherapy. The efficacy of radiation therapy in this setting has not been established.<\/jats:p>\n <\/jats:sec>\n \n Case Report<\/jats:title>\n Medical records were retrospectively reviewed for FeLV\u2010positive cats diagnosed with mediastinal lymphoma between November 2018 and December 2024 that had persistent or progressive mediastinal disease after chemotherapy and were subsequently treated with radiation therapy. Treatment response was assessed by computed tomography using the Response Evaluation Criteria in Solid Tumours (RECIST). Three of four cats (75%) responded to radiation therapy (two complete responses, one partial response). Respiratory signs improved rapidly in three cats (median 5\u2009days). Local disease control was achieved in most cases; however, three cats developed progression at other sites. Survival times were 45, 150 and 352\u2009days in cats that died, and one cat remained alive for >626\u2009days at the time of last follow\u2010up. No severe radiation\u2010related adverse effects were documented during the available follow\u2010up, although systematic evaluation of late radiation toxicity was not possible.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Radiation therapy may provide local control and rapid palliation of respiratory signs in FeLV\u2010positive cats with persistent or progressive mediastinal lymphoma after chemotherapy. Further studies with larger cohorts are warranted.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/avj.70150","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:40:00Z","timestamp":1791967200000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Radiation therapy for persistent or progressive mediastinal lymphoma after chemotherapy in\n FeLV<\/scp>\n \u2010positive cats: a retrospective case series of four cats"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9549-0395","authenticated-orcid":false,"given":"A","family":"Uno","sequence":"first","affiliation":[{"name":"Animal Medical Center, Gifu University Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Animal Medical Center, Gifu University Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6112-8081","authenticated-orcid":false,"given":"T","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Gifu University Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1053\/jfms.2000.0079","article-title":"Advances in the treatment of the cat with lymphoma in practice","volume":"2","author":"Couto CG","year":"2000","journal-title":"J Feline Med Surg"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1748-5827.1996.tb01772.x","article-title":"Pleural effusion in cats: 82 cases (1987 to 1995)","volume":"37","author":"Davies C","year":"1996","journal-title":"J Small Anim Pract"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1748-5827.1997.tb03492.x","article-title":"Review of thymic pathology in 30 cats and 36 dogs","volume":"38","author":"Day MJ","year":"1997","journal-title":"J Small Anim Pract"},{"key":"e_1_2_10_5_1","first-page":"329","article-title":"Feline lymphoma in the post\u2010feline leukemia virus era","volume":"19","author":"Louwerens M","year":"2005","journal-title":"J Vet Intern Med"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1939-1676.1998.tb02134.x","article-title":"Feline lymphoma (145 cases): proliferation indices, cluster of differentiation 3 immunoreactivity, and their association with prognosis in 90 cats","volume":"12","author":"Vail DM","year":"1998","journal-title":"J Vet Intern Med"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.1748-5827.2010.00915.x","article-title":"Feline paediatric oncology: retrospective assessment of 233 tumours from cats up to one year (1993 to 2008)","volume":"51","author":"Schmidt JM","year":"2010","journal-title":"J Small Anim Pract"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1751-0813.1998.tb12300.x","article-title":"Clinical and anatomical features of lymphosarcoma in 118 cats","volume":"76","author":"Gabor LJ","year":"1998","journal-title":"Aust Vet J"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/j.1751-0813.1999.tb12085.x","article-title":"Immunophenotypic and histological characterisation of 109 cases of feline lymphosarcoma","volume":"77","author":"Gabor LJ","year":"1999","journal-title":"Aust Vet J"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1177\/1098612X13516621","article-title":"Feline mediastinal lymphoma: a retrospective study of signalment, retroviral status, response to chemotherapy and prognostic indicators","volume":"16","author":"Fabrizio F","year":"2014","journal-title":"J Feline Med Surg"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1751-0813.1997.tb14347.x","article-title":"Retrospective study of 60 cases of feline lymphosarcoma","volume":"75","author":"Court EA","year":"1997","journal-title":"Aust Vet J"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/vco.12158","article-title":"Treatment of feline intermediate\u2010 to\u2009high\u2010grade lymphoma with a modified University of Wisconsin\u2013Madison protocol: 119 cases (2004\u20132012)","volume":"14","author":"Collete AS","year":"2016","journal-title":"Vet Comp Oncol"},{"key":"e_1_2_10_13_1","first-page":"166","article-title":"Treatment of lymphoma and leukemia with cyclophosphamide, vincristine, and prednisone: II. 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