{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:47:28Z","timestamp":1791935248342,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"abstract":"<jats:p>\n                    A 12\u2010year\u2010old female spayed Irish wolfhound presented with a 6\u2010month history of weight loss, chronic vomiting and diarrhoea and a persistent progressive lymphocytosis with previously diagnosed CD8+ T\u2010cell chronic lymphocytic leukaemia (CLL). CLL was initially diagnosed through flow cytometry of EDTA\u2010preserved peripheral blood. The decision to treat was based on a progressive circulating neoplastic lymphocytic population in the face of clinical deterioration. Progressive clinical decline was identified in the several weeks after commencement of treatment with chlorambucil and pegylated asparaginase for progressive CLL. Repeated haemogram and blood smear were suggestive of a second morphologically distinct circulating neoplastic population. Repeated flow cytometry of peripheral blood was consistent with a concurrent acute myeloid leukaemia (AML) to previously identified CD8+ CLL. Emergence of AML coincided with development of upwards of five cutaneous lesions, with concern for leukaemia cutis. High\u2010dose chemotherapy with vincristine (0.7\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) was commenced. Despite more aggressive treatment, rapid clinical deterioration ensued, and euthanasia was elected. To the author's knowledge, this is the first report of diagnosis of concurrent AML and CLL in a dog.\n                  <\/jats:p>","DOI":"10.1111\/avj.70153","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:20:28Z","timestamp":1791933628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnosis of acute myeloid leukaemia in a previously diagnosed case of chronic lymphocytic leukaemia in a dog"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8228-5967","authenticated-orcid":false,"given":"I","family":"Geh","sequence":"first","affiliation":[{"name":"Animal Referral Hospital  Sinnamon Park Queensland 4073 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Animal Referral Hospital  Sinnamon Park Queensland 4073 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Morgan","sequence":"additional","affiliation":[{"name":"Animal Referral Hospital  Sinnamon Park Queensland 4073 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1939-1676.2010.0640.x","article-title":"Immunophenotype predicts survival time in dogs with chronic lymphocytic leukemia","volume":"25","author":"Comazzi S","year":"2011","journal-title":"J Vet Intern Med"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","article-title":"The 5th edition of the World Health Organization classification of Haematolymphoid Tumours: myeloid and histiocytic\/dendritic neoplasms","volume":"36","author":"Khoury JD","year":"2022","journal-title":"Leukemia"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/vco.12377","article-title":"A retrospective review of acute myeloid leukaemia in 35 dogs diagnosed by a combination of morphologic findings, flow cytometric immunophenotyping and cytochemical staining results (2007\u20102015)","volume":"16","author":"Davis LL","year":"2018","journal-title":"Vet Comp Oncol"},{"key":"e_1_2_9_5_1","first-page":"77","article-title":"Therapy related AML in a case of chronic lymphocytic leukemia","volume":"13","author":"Gajendra S","year":"2023","journal-title":"Am J Blood Res"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1200\/JCO.2008.17.5398","article-title":"Other malignancies in chronic lymphocytic leukemia\/small lymphocytic lymphoma","volume":"27","author":"Tsimberidou A\u2010M","year":"2009","journal-title":"J Clin Oncol"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1002\/1097-0142(19810401)47:7<1849::AID-CNCR2820470722>3.0.CO;2-X","article-title":"Chronic lymphatic leukemia terminating in acute myeloid leukemia: review of the literature","volume":"47","author":"Stern N","year":"1981","journal-title":"Cancer"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s11864-004-0013-7","article-title":"Second neoplasms in patients with chronic lymphocytic leukemia","volume":"5","author":"Wiernik PH","year":"2004","journal-title":"Curr Treat Options Oncol"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2025-014099","article-title":"Immunological consequences of chemotherapy: implications for cancer immunotherapy","volume":"14","author":"Bishara GG","year":"2026","journal-title":"J Immunother Cancer"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1002\/1097-0142(19890401)63:7<1398::AID-CNCR2820630727>3.0.CO;2-F","article-title":"Concomitant chronic lymphocytic leukemia, acute myeloid leukemia, and thrombosis with protein C deficiency. 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