{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:34:06Z","timestamp":1788194046780,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T00:00:00Z","timestamp":1365379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2013,5]]},"abstract":"Aim<\/jats:title>Studies of the carcinogenic potential of benzodiazepines and related drugs (BZRD<\/jats:styled-content>) have been equivocal. A recent study reported a 35% excess cancer risk among users of hypnotics, including benzodiazepines.<\/jats:p><\/jats:sec>Method<\/jats:title>Using D<\/jats:styled-content>anish nationwide registers, we conducted a matched case\u2013control study of the association between BZRD<\/jats:styled-content> and cancer risk. During 1 January 2002 and 31 December 2009, we identified 152\u2009510 cases with a first time cancer who were matched (1:8) by age and gender to 1\u2009220\u2009317 cancer\u2010free controls. A new\u2010user design was applied by excluding all subjects who had used anxiolytics, hypnotics or sedatives during the first 2 years of available prescription data (1995\u20136). Odds ratios (ORs<\/jats:styled-content>) with 95% confidence intervals (CI<\/jats:styled-content>) were estimated using conditional logistic regression, adjusting for potential confounders. In the primary analysis, long term use of BZRD<\/jats:styled-content> was defined by a cumulative amount of \u2265500 defined daily doses of BZRD<\/jats:styled-content> within a period of 1 to 5 years prior to the index date.<\/jats:p><\/jats:sec>Results<\/jats:title>The adjusted OR<\/jats:styled-content> for cancer associated with BZRD<\/jats:styled-content> use was 1.09 (95% CI<\/jats:styled-content> 1.04, 1.14). ORs<\/jats:styled-content> were close to unity for most cancer sites, except stomach 1.40 (95% CI<\/jats:styled-content> 1.05, 1.88), oesophagus 1.43 (95% CI<\/jats:styled-content> 1.01, 2.02), liver 1.81 (95% CI<\/jats:styled-content> 1.18, 2.80), lung 1.38 (95% CI<\/jats:styled-content> 1.23, 1.54), pancreas 1.35 (95% CI<\/jats:styled-content> 1.02, 1.79) and kidney 1.39 (95% CI<\/jats:styled-content> 1.01, 1.91). For tobacco\u2010related cancers, the OR<\/jats:styled-content> was 1.15 (95% CI<\/jats:styled-content> 1.09, 1.22) and for the remaining cancer sites 1.01 (95% CI<\/jats:styled-content> 0.94, 1.08). Sub\u2010group analyses revealed only small differences between different levels of exposure or different patient subgroups.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>BZRD<\/jats:styled-content> use was not associated with an overall increase in cancer risk, except for what is likely explained by minor lifestyle confounding, e.g. smoking.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.12001","type":"journal-article","created":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T09:27:05Z","timestamp":1349774825000},"page":"1356-1364","source":"Crossref","is-referenced-by-count":43,"title":["Use of benzodiazepines or benzodiazepine related drugs and the risk of cancer: a population\u2010based case\u2010control study"],"prefix":"10.1111","volume":"75","author":[{"given":"Anton","family":"Potteg\u00e5rd","sequence":"first","affiliation":[{"name":"Clinical Pharmacology Institute of Public Health University of Southern Denmark DK\u20105000 Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Friis","sequence":"additional","affiliation":[{"name":"Danish Cancer Society Research Center Danish Cancer Society DK\u20102100 Copenhagen \u00d8 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Andersen","sequence":"additional","affiliation":[{"name":"Centre for Pharmacoepidemiology Karolinska Institutet Unit of Clinical Epidemiology Karolinska University Hospital SE\u201017177 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Hallas","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Institute of Public Health University of Southern Denmark DK\u20105000 Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,8]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"72","article-title":"Prevalence and potential consequences of benzodiazepine use in senior citizens: results from the Canadian Study of Health and Aging","volume":"10","author":"Hogan DB","year":"2003","journal-title":"Can J Clin Pharmacol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2003.08.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0161-4630(79)90103-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgg011"},{"key":"e_1_2_8_6_1","unstructured":"International Agency for Research on Cancer (IARC).IARC monograph volume 66.1996. 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