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Cyst initiation and expansion arise from a combination of abnormal cell proliferation, fluid secretion and extracellular matrix defects and results in kidney enlargement and interstitial fibrosis. Since its first description over 200 years ago, <jats:styled-content style=\"fixed-case\">ADPKD<\/jats:styled-content> has been considered an untreatable condition and its management is limited to blood pressure reduction and symptomatic treatment of disease complications. Results of the recently reported <jats:styled-content style=\"fixed-case\">TEMPO<\/jats:styled-content> 3\/4 trial thus represent a paradigm shift in demonstrating for the first time that cystic disease and loss of renal function can be slowed in humans. In this paper, we review the major therapeutic strategies currently being explored in <jats:styled-content style=\"fixed-case\">ADPKD<\/jats:styled-content> including a range of novel approaches in preclinical models. It is anticipated that the clinical management of <jats:styled-content style=\"fixed-case\">ADPKD<\/jats:styled-content> will undergo a revolution in the next decade with the translation of new treatments into routine clinical use.<\/jats:p>","DOI":"10.1111\/bcp.12136","type":"journal-article","created":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T07:57:05Z","timestamp":1366271825000},"page":"524-535","source":"Crossref","is-referenced-by-count":38,"title":["New treatments for autosomal dominant polycystic kidney disease"],"prefix":"10.1111","volume":"76","author":[{"given":"Ming\u2010Yang","family":"Chang","sequence":"first","affiliation":[{"name":"Kidney Research Center Department of Nephrology Chang Gung Memorial Hospital Chang Gung University College of Medicine  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert C. 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