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This review discusses the literature concerning the role of\n                    <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                    \u2010type calcium channels in physiological and pathological processes related to epilepsy.\n                    <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                    \u2010type calcium channels have been implicated in pathology of both the genetic and acquired epilepsies and several anti\u2010epileptic drugs (\n                    <jats:styled-content style=\"fixed-case\">AEDs<\/jats:styled-content>\n                    ) in clinical use are known to suppress seizures via inhibition of\n                    <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                    \u2010type calcium channels. Despite the fact that more than 15 new\n                    <jats:styled-content style=\"fixed-case\">AEDs<\/jats:styled-content>\n                    have become clinically available over the past 20 years at least 30% of epilepsy patients still fail to achieve seizure control, and many patients experience unwanted side effects. Furthermore there are no treatments that prevent the development of epilepsy or mitigate the epileptic state once established. Therefore there is an urgent need for the development of new\n                    <jats:styled-content style=\"fixed-case\">AEDs<\/jats:styled-content>\n                    that are effective in patients with drug resistant epilepsy, are anti\u2010epileptogenic and are better tolerated. We also review the mechanisms of action of the current\n                    <jats:styled-content style=\"fixed-case\">AEDs<\/jats:styled-content>\n                    with known effects on\n                    <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                    \u2010type calcium channels and discuss novel compounds that are being investigated as new treatments for epilepsy.\n                  <\/jats:p>","DOI":"10.1111\/bcp.12205","type":"journal-article","created":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T08:06:06Z","timestamp":1373357166000},"page":"729-739","source":"Crossref","is-referenced-by-count":80,"title":["Low threshold\n                    <scp>T<\/scp>\n                    \u2010type calcium channels as targets for novel epilepsy treatments"],"prefix":"10.1111","volume":"77","author":[{"given":"Kim L.","family":"Powell","sequence":"first","affiliation":[{"name":"Department of Medicine Royal Melbourne Hospital University of 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