{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:54:51Z","timestamp":1792101291264,"version":"4.4.0"},"reference-count":72,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":557,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1111\/bcp.12207","type":"journal-article","created":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T12:06:29Z","timestamp":1373371589000},"page":"554-570","source":"Crossref","is-referenced-by-count":108,"title":["Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19"],"prefix":"10.1111","volume":"77","author":[{"given":"Alice Ban","family":"Ke","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics; University of Washington; Seattle WA USA"},{"name":"Office of Clinical Pharmacology; Office of Translational Sciences; Center for Drug Evaluation and Research; Food and Drug Administration; Silver Spring MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikanth C.","family":"Nallani","sequence":"additional","affiliation":[{"name":"Office of Clinical Pharmacology; Office of Translational Sciences; Center for Drug Evaluation and Research; Food and Drug Administration; Silver Spring MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhao","sequence":"additional","affiliation":[{"name":"Office of Clinical Pharmacology; Office of Translational Sciences; Center for Drug Evaluation and Research; Food and Drug Administration; Silver Spring MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Rostami-Hodjegan","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences; University of Manchester; Manchester and"},{"name":"Simcyp Limited (now part of Certara); Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jashvant D.","family":"Unadkat","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics; University of Washington; Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,21]]},"reference":[{"key":"10.1111\/bcp.12207-BIB0001|bcp12207-cit-0001","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1111\/j.1365-2125.2012.04280.x","article-title":"The status of pharmacometrics in pregnancy: highlights from the 3(rd) American Conference on Pharmacometrics","volume":"74","author":"Hasselt","year":"2012","journal-title":"Br J Clin Pharmacol"},{"key":"10.1111\/bcp.12207-BIB0002|bcp12207-cit-0002","first-page":"1","article-title":"Altered methadone pharmacokinetics in methadone-maintained pregnant women","volume":"233","author":"Pond","year":"1985","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1111\/bcp.12207-BIB0003|bcp12207-cit-0003","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1097\/JCP.0b013e3182664ecd","article-title":"Pharmacokinetic-pharmacodynamic modeling of mood and withdrawal symptoms in relation to plasma concentrations of methadone in patients undergoing methadone maintenance treatment","volume":"32","author":"Shiran","year":"2012","journal-title":"J Clin Psychopharmacol"},{"key":"10.1111\/bcp.12207-BIB0004|bcp12207-cit-0004","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1067\/mcp.2002.122476","article-title":"Impact of CYP2C9 amino acid polymorphisms on glyburide kinetics and on the insulin and glucose response in healthy volunteers","volume":"71","author":"Kirchheiner","year":"2002","journal-title":"Clin Pharmacol Ther"},{"key":"10.1111\/bcp.12207-BIB0005|bcp12207-cit-0005","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/clpt.2009.5","article-title":"Are we optimizing gestational diabetes treatment with glyburide? The pharmacologic basis for better clinical practice","volume":"85","author":"Hebert","year":"2009","journal-title":"Clin Pharmacol Ther"},{"key":"10.1111\/bcp.12207-BIB0006|bcp12207-cit-0006","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1517\/17425255.3.4.557","article-title":"Alterations in drug disposition during pregnancy: implications for drug therapy","volume":"3","author":"Hodge","year":"2007","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1111\/bcp.12207-BIB0007|bcp12207-cit-0007","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1517\/17425251003677755","article-title":"Altered drug metabolism during pregnancy: hormonal regulation of drug-metabolizing enzymes","volume":"6","author":"Jeong","year":"2010","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1111\/bcp.12207-BIB0008|bcp12207-cit-0008","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev-pharmtox-010510-100540","article-title":"Physiologically-based pharmacokinetics in drug development and regulatory science","volume":"51","author":"Rowland","year":"2011","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1111\/bcp.12207-BIB0009|bcp12207-cit-0009","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2133\/dmpk.24.53","article-title":"A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: a tale of \u2018bottom-up\u2019 vs \u2018top-down\u2019 recognition of covariates","volume":"24","author":"Jamei","year":"2009","journal-title":"Drug Metab Pharmacokinet"},{"key":"10.1111\/bcp.12207-BIB0010|bcp12207-cit-0010","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/j.1365-2125.2012.04363.x","article-title":"A pregnancy physiologically-based pharmacokinetic (p-PBPK) model for disposition of drugs metabolized by CYP1A2, CYP3A4 and CYP2D6","volume":"74","author":"Lu","year":"2012","journal-title":"Br J Clin Pharmacol"},{"key":"10.1111\/bcp.12207-BIB0011|bcp12207-cit-0011","doi-asserted-by":"crossref","first-page":"365","DOI":"10.2165\/11597440-000000000-00000","article-title":"Anatomical, physiological and metabolic changes with gestational age during normal pregnancy: a database for parameters required in physiologically based pharmacokinetic modelling","volume":"51","author":"Abduljalil","year":"2012","journal-title":"Clin Pharmacokinet"},{"key":"10.1111\/bcp.12207-BIB0012|bcp12207-cit-0012","doi-asserted-by":"crossref","DOI":"10.1038\/psp.2012.2","article-title":"A PBPK model to predict disposition of CYP3A-metabolized drugs in pregnant women: verification and discerning the site of CYP3A induction","volume":"1","author":"Ke","year":"2012","journal-title":"Clin Pharmacol Ther"},{"key":"10.1111\/bcp.12207-BIB0013|bcp12207-cit-0013","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1124\/dmd.112.050161","article-title":"A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women","volume":"41","author":"Ke","year":"2013","journal-title":"Drug Metab Dispos"},{"key":"10.1111\/bcp.12207-BIB0014|bcp12207-cit-0014","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/bcp.12078","article-title":"Reduced indinavir exposure during pregnancy","volume":"76","author":"Cressey","year":"2013","journal-title":"Br J Clin Pharmacol"},{"key":"10.1111\/bcp.12207-BIB0015|bcp12207-cit-0015","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1528-1157.1994.tb02921.x","article-title":"Epilepsy and pregnancy: a prospective study of seizure control in relation to free and total plasma concentrations of carbamazepine and phenytoin","volume":"35","author":"Tomson","year":"1994","journal-title":"Epilepsia"},{"key":"10.1111\/bcp.12207-BIB0016|bcp12207-cit-0016","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1528-1157.1994.tb02922.x","article-title":"Disposition of carbamazepine and phenytoin in pregnancy","volume":"35","author":"Tomson","year":"1994","journal-title":"Epilepsia"},{"key":"10.1111\/bcp.12207-BIB0017|bcp12207-cit-0017","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00228-003-0652-9","article-title":"The pharmacokinetics of atovaquone and proguanil in pregnant women with acute falciparum malaria","volume":"59","author":"McGready","year":"2003","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1111\/bcp.12207-BIB0018|bcp12207-cit-0018","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00228-003-0651-x","article-title":"Pregnancy and use of oral contraceptives reduces the biotransformation of proguanil to cycloguanil","volume":"59","author":"McGready","year":"2003","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1111\/bcp.12207-BIB0019|bcp12207-cit-0019","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/ALN.0b013e3181642938","article-title":"Role of CYP2B6 in stereoselective human methadone metabolism","volume":"108","author":"Totah","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1111\/bcp.12207-BIB0020|bcp12207-cit-0020","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/ALN.0b013e3181986a9a","article-title":"Methadone pharmacokinetics are independent of cytochrome P4503A (CYP3A) activity and gastrointestinal drug transport: insights from methadone interactions with ritonavir\/indinavir","volume":"110","author":"Kharasch","year":"2009","journal-title":"Anesthesiology"},{"key":"10.1111\/bcp.12207-BIB0021|bcp12207-cit-0021","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1046\/j.1365-2125.2000.00272.x","article-title":"Steady-state pharmacokinetics of (R)- and (S)-methadone in methadone maintenance patients","volume":"50","author":"Foster","year":"2000","journal-title":"Br J Clin Pharmacol"},{"key":"10.1111\/bcp.12207-BIB0022|bcp12207-cit-0022","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.2165\/00003088-200241140-00003","article-title":"Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence","volume":"41","author":"Eap","year":"2002","journal-title":"Clin Pharmacokinet"},{"key":"10.1111\/bcp.12207-BIB0023|bcp12207-cit-0023","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1124\/jpet.106.117580","article-title":"Enantiomeric metabolic interactions and stereoselective human methadone metabolism","volume":"321","author":"Totah","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1111\/bcp.12207-BIB0024|bcp12207-cit-0024","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1592\/phco.28.7.863","article-title":"Pharmacokinetics and pharmacodynamics of methadone enantiomers after coadministration with fosamprenavir-ritonavir in opioid-dependent subjects","volume":"28","author":"Cao","year":"2008","journal-title":"Pharmacotherapy"},{"key":"10.1111\/bcp.12207-BIB0025|bcp12207-cit-0025","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1128\/AAC.00559-06","article-title":"Pharmacokinetic interaction between voriconazole and methadone at steady state in patients on methadone therapy","volume":"51","author":"Liu","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1111\/bcp.12207-BIB0026|bcp12207-cit-0026","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.clpt.2004.05.003","article-title":"Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone","volume":"76","author":"Kharasch","year":"2004","journal-title":"Clin Pharmacol Ther"},{"key":"10.1111\/bcp.12207-BIB0027|bcp12207-cit-0027","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1056-8719(00)00043-5","article-title":"Methadone: a review of its pharmacokinetic\/pharmacodynamic properties","volume":"42","author":"Garrido","year":"1999","journal-title":"J Pharmacol Toxicol Methods"},{"key":"10.1111\/bcp.12207-BIB0028|bcp12207-cit-0028","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1067\/mcp.2001.116793","article-title":"Pharmacokinetics and pharmacodynamics of methadone enantiomers after a single oral dose of racemate","volume":"70","author":"Boulton","year":"2001","journal-title":"Clin Pharmacol Ther"},{"key":"10.1111\/bcp.12207-BIB0029|bcp12207-cit-0029","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1124\/dmd.112.047118","article-title":"Quantitative prediction of CYP2B6 induction by estradiol during pregnancy, potential explanation for increased methadone clearance during pregnancy","volume":"41","author":"Dickmann","year":"2012","journal-title":"Drug Metab Dispos"},{"key":"10.1111\/bcp.12207-BIB0030|bcp12207-cit-0030","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1124\/dmd.112.046276","article-title":"Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone","volume":"41","author":"Choi","year":"2012","journal-title":"Drug Metab Dispos"},{"key":"10.1111\/bcp.12207-BIB0031|bcp12207-cit-0031","unstructured":"http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2006\/022001lbl.pdf"},{"key":"10.1111\/bcp.12207-BIB0032|bcp12207-cit-0032","unstructured":"http:\/\/www.pbs.gov.au\/meds%2Fpi%2Fafpglime10808.pdf"},{"key":"10.1111\/bcp.12207-BIB0033|bcp12207-cit-0033","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/clpt.2008.186","article-title":"Elucidating rifampin's inducing and inhibiting effects on glyburide pharmacokinetics and blood glucose in healthy volunteers: unmasking the differential effects of enzyme induction and transporter inhibition for a drug and its primary metabolite","volume":"85","author":"Zheng","year":"2009","journal-title":"Clin Pharmacol Ther"},{"key":"10.1111\/bcp.12207-BIB0034|bcp12207-cit-0034","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.bcp.2009.08.003","article-title":"Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburide","volume":"78","author":"Zharikova","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"10.1111\/bcp.12207-BIB0035|bcp12207-cit-0035","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/bdd.706","article-title":"Contributions of human cytochrome P450 enzymes to glyburide metabolism","volume":"31","author":"Zhou","year":"2010","journal-title":"Biopharm Drug Dispos"},{"key":"10.1111\/bcp.12207-BIB0036|bcp12207-cit-0036","doi-asserted-by":"crossref","first-page":"29A","DOI":"10.1016\/S0002-9149(05)80012-8","article-title":"Lack of interaction between fluvastatin and oral hypoglycemic agents in healthy subjects and in patients with non-insulin-dependent diabetes mellitus","volume":"76","author":"Appel","year":"1995","journal-title":"Am J Cardiol"},{"key":"10.1111\/bcp.12207-BIB0037|bcp12207-cit-0037","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1067\/mcp.2002.127495","article-title":"Glyburide and glimepiride pharmacokinetics in subjects with different CYP2C9 genotypes","volume":"72","author":"Niemi","year":"2002","journal-title":"Clin Pharmacol Ther"},{"key":"10.1111\/bcp.12207-BIB0038|bcp12207-cit-0038","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1124\/dmd.104.002337","article-title":"Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B","volume":"33","author":"Satoh","year":"2005","journal-title":"Drug Metab Dispos"},{"key":"10.1111\/bcp.12207-BIB0039|bcp12207-cit-0039","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1124\/dmd.106.009290","article-title":"Drug-drug interaction between pitavastatin and various drugs via OATP1B1","volume":"34","author":"Hirano","year":"2006","journal-title":"Drug Metab Dispos"},{"key":"10.1111\/bcp.12207-BIB0040|bcp12207-cit-0040","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1080\/00498250410001685728","article-title":"Identification and relative contributions of human cytochrome P450 isoforms involved in the metabolism of glibenclamide and lansoprazole: evaluation of an approach based on the in vitro substrate disappearance rate","volume":"34","author":"Naritomi","year":"2004","journal-title":"Xenobiotica"},{"key":"10.1111\/bcp.12207-BIB0041|bcp12207-cit-0041","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1007\/s11095-012-0792-7","article-title":"Physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions","volume":"29","author":"Varma","year":"2012","journal-title":"Pharm Res"},{"key":"10.1111\/bcp.12207-BIB0042|bcp12207-cit-0042","first-page":"730","article-title":"Inhibition by omeprazole of proguanil metabolism: mechanism of the interaction in vitro and prediction of in vivo results from the in vitro experiments","volume":"280","author":"Funck-Brentano","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1111\/bcp.12207-BIB0043|bcp12207-cit-0043","unstructured":"http:\/\/www.gsk.ca\/english\/docs-pdf\/Malarone_PM_EN_20071102.pdf"},{"key":"10.1111\/bcp.12207-BIB0044|bcp12207-cit-0044","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/j.1365-2125.1987.tb03245.x","article-title":"Single dose pharmacokinetics of proguanil and its metabolites in healthy subjects","volume":"24","author":"Wattanagoon","year":"1987","journal-title":"Br J Clin Pharmacol"},{"key":"10.1111\/bcp.12207-BIB0045|bcp12207-cit-0045","doi-asserted-by":"crossref","first-page":"420","DOI":"10.2174\/138920009788498978","article-title":"Towards a quantitative framework for the prediction of DDIs arising from cytochrome P450 induction","volume":"10","author":"Almond","year":"2009","journal-title":"Curr Drug Metab"},{"key":"10.1111\/bcp.12207-BIB0046|bcp12207-cit-0046","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/clpt.1991.49","article-title":"Effect of fluconazole on the disposition of phenytoin","volume":"49","author":"Blum","year":"1991","journal-title":"Clin Pharmacol Ther"},{"key":"10.1111\/bcp.12207-BIB0047|bcp12207-cit-0047","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0920-1211(90)90042-T","article-title":"Pharmacokinetics of anticonvulsants in pregnancy: alterations in plasma protein binding","volume":"5","author":"Yerby","year":"1990","journal-title":"Epilepsy Res"},{"key":"10.1111\/bcp.12207-BIB0048|bcp12207-cit-0048","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/sj.clpt.6100038","article-title":"effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers","volume":"81","author":"Lau","year":"2007","journal-title":"Clin Pharmacol Ther"},{"key":"10.1111\/bcp.12207-BIB0049|bcp12207-cit-0049","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2165\/00003088-200544100-00001","article-title":"Pregnancy-induced changes in pharmacokinetics: a mechanistic-based approach","volume":"44","author":"Anderson","year":"2005","journal-title":"Clin Pharmacokinet"},{"key":"10.1111\/bcp.12207-BIB0050|bcp12207-cit-0050","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/clinchem\/37.5.667","article-title":"Longitudinal assessment of changes in reproductive hormones during normal pregnancy","volume":"37","author":"O'Leary","year":"1991","journal-title":"Clin Chem"},{"key":"10.1111\/bcp.12207-BIB0051|bcp12207-cit-0051","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00228-005-0035-5","article-title":"Changes to methadone clearance during pregnancy","volume":"61","author":"Wolff","year":"2005","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1111\/bcp.12207-BIB0052|bcp12207-cit-0052","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1300\/J069v18n04_05","article-title":"Alterations in methadone metabolism during late pregnancy","volume":"18","author":"Jarvis","year":"1999","journal-title":"J Addict Dis"},{"key":"10.1111\/bcp.12207-BIB0053|bcp12207-cit-0053","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/clpt.2012.61","article-title":"Pharmacokinetic and pharmacodynamic analysis of efavirenz dose reduction using an in vitro-in vivo extrapolation model","volume":"92","author":"Siccardi","year":"2012","journal-title":"Clin Pharmacol Ther"},{"key":"10.1111\/bcp.12207-BIB0054|bcp12207-cit-0054","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/QAI.0b013e31823ff052","article-title":"Efavirenz pharmacokinetics during the third trimester of pregnancy and postpartum","volume":"59","author":"Cressey","year":"2012","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1111\/bcp.12207-BIB0055|bcp12207-cit-0055","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1124\/mol.110.065540","article-title":"Regulation of CYP2C19 expression by estrogen receptor alpha: implications for estrogen-dependent inhibition of drug metabolism","volume":"78","author":"Mwinyi","year":"2010","journal-title":"Mol Pharmacol"},{"key":"10.1111\/bcp.12207-BIB0056|bcp12207-cit-0056","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1097\/00126334-200408150-00006","article-title":"Coadministration of lopinavir\/ritonavir and phenytoin results in two-way drug interaction through cytochrome P-450 induction","volume":"36","author":"Lim","year":"2004","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1111\/bcp.12207-BIB0057|bcp12207-cit-0057","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1128\/AAC.45.9.2543-2552.2001","article-title":"Drug interactions with clinafloxacin","volume":"45","author":"Randinitis","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl 1","key":"10.1111\/bcp.12207-BIB0058|bcp12207-cit-0058","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1046\/j.1365-2125.2003.01997.x","article-title":"Coadministration of voriconazole and phenytoin: pharmacokinetic interaction, safety, and toleration","volume":"56","author":"Purkins","year":"2003","journal-title":"Br J Clin Pharmacol"},{"key":"10.1111\/bcp.12207-BIB0059|bcp12207-cit-0059","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1365-2710.1995.tb00664.x","article-title":"Comparison of the kinetics of glyburide and its active metabolites in humans","volume":"20","author":"Rydberg","year":"1995","journal-title":"J Clin Pharm Ther"},{"key":"10.1111\/bcp.12207-BIB0060|bcp12207-cit-0060","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1124\/dmd.109.030791","article-title":"Breast cancer resistance protein (BCRP)-mediated glyburide transport: effect of the C421A\/Q141K BCRP single-nucleotide polymorphism","volume":"38","author":"Pollex","year":"2010","journal-title":"Drug Metab Dispos"},{"key":"10.1111\/bcp.12207-BIB0061|bcp12207-cit-0061","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1124\/dmd.112.050161","article-title":"A PBPK model to predict disposition of P450 2D6 and P450 1A2 metabolized drugs in pregnant women","volume":"41","author":"Ke","year":"2013","journal-title":"Drug Metab Dispos"},{"key":"10.1111\/bcp.12207-BIB0062|bcp12207-cit-0062","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/00126334-200106010-00010","article-title":"Effect of ritonavir\/saquinavir on stereoselective pharmacokinetics of methadone: results of AIDS Clinical Trials Group (ACTG) 401","volume":"27","author":"Gerber","year":"2001","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1111\/bcp.12207-BIB0063|bcp12207-cit-0063","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/clpt.1990.37","article-title":"Binding of d-methadone, l-methadone, and dl-methadone to proteins in plasma of healthy volunteers: role of the variants of alpha 1-acid glycoprotein","volume":"47","author":"Eap","year":"1990","journal-title":"Clin Pharmacol Ther"},{"key":"10.1111\/bcp.12207-BIB0064|bcp12207-cit-0064","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1365-2125.2004.02116.x","article-title":"Bioavailabilities of rectal and oral methadone in healthy subjects","volume":"58","author":"Dale","year":"2004","journal-title":"Br J Clin Pharmacol"},{"key":"10.1111\/bcp.12207-BIB0065|bcp12207-cit-0065","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1046\/j.1360-0443.2000.951217717.x","article-title":"Population-based pharmacokinetic approach for methadone monitoring of opiate addicts: potential clinical utility","volume":"95","author":"Wolff","year":"2000","journal-title":"Addiction"},{"key":"10.1111\/bcp.12207-BIB0066|bcp12207-cit-0066","doi-asserted-by":"crossref","first-page":"676","DOI":"10.2174\/138920007782109733","article-title":"Prediction of intestinal first-pass drug metabolism","volume":"8","author":"Yang","year":"2007","journal-title":"Curr Drug Metab"},{"key":"10.1111\/bcp.12207-BIB0067|bcp12207-cit-0067","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1007\/s11095-006-9210-3","article-title":"Mechanistic approaches to volume of distribution predictions: understanding the processes","volume":"24","author":"Rodgers","year":"2007","journal-title":"Pharm Res"},{"key":"10.1111\/bcp.12207-BIB0068|bcp12207-cit-0068","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1023\/A:1011900527021","article-title":"Co-administration of a water-soluble polymer increases the usefulness of cyclodextrins in solid oral dosage forms","volume":"15","author":"Savolainen","year":"1998","journal-title":"Pharm Res"},{"key":"10.1111\/bcp.12207-BIB0069|bcp12207-cit-0069","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1124\/dmd.108.020479","article-title":"Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds","volume":"36","author":"Obach","year":"2008","journal-title":"Drug Metab Dispos"},{"key":"10.1111\/bcp.12207-BIB0070|bcp12207-cit-0070","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2125.1997.00571.x","article-title":"Concentration-effect relations of glibenclamide and its active metabolites in man: modelling of pharmacokinetics and pharmacodynamics","volume":"43","author":"Rydberg","year":"1997","journal-title":"Br J Clin Pharmacol"},{"key":"10.1111\/bcp.12207-BIB0071|bcp12207-cit-0071","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1067\/mcp.2001.115822","article-title":"Effects of rifampin on the pharmacokinetics and pharmacodynamics of glyburide and glipizide","volume":"69","author":"Niemi","year":"2001","journal-title":"Clin Pharmacol Ther"},{"key":"10.1111\/bcp.12207-BIB0072|bcp12207-cit-0072","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1177\/0091270009338938","article-title":"Coadministration of pioglitazone or glyburide and alogliptin: pharmacokinetic drug interaction assessment in healthy participants","volume":"49","author":"Karim","year":"2009","journal-title":"J Clin Pharmacol"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcp.12207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/bcp.12207\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T04:29:24Z","timestamp":1715660964000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcp.12207"}},"subtitle":["PBPK prediction of PK changes during pregnancy"],"short-title":[],"issued":{"date-parts":[[2014,2,21]]},"references-count":72,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"URL":"https:\/\/doi.org\/10.1111\/bcp.12207","relation":{},"ISSN":["0306-5251"],"issn-type":[{"value":"0306-5251","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2,21]]}}}