{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:19:08Z","timestamp":1790619548112,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T00:00:00Z","timestamp":1398124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Few well\u2010designed randomized controlled trials have been conducted regarding the impact of community pharmacist interventions on pharmacotherapeutic monitoring of patients with chronic obstructive pulmonary disease (<jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>). We assessed the effectiveness of a pharmaceutical care programme for patients with <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The pharmaceutical care for patients with <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">PHARMACOP<\/jats:styled-content>) trial is a single\u2010blind 3\u2009month randomized controlled trial, conducted in 170 community pharmacies in <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>elgium, enrolling patients prescribed daily <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> medication, aged \u226550\u2009years and with a smoking history of \u226510 pack\u2010years. A computer\u2010generated randomization sequence allocated patients to an intervention group (<jats:italic>n<\/jats:italic> = 371), receiving protocol\u2010defined pharmacist care, or a control group (<jats:italic>n<\/jats:italic> = 363), receiving usual pharmacist care (1:1 ratio, stratified by centre). Interventions focusing on inhalation technique and adherence to maintenance therapy were carried out at start of the trial and at 1\u2009month follow\u2010up. Primary outcomes were inhalation technique and medication adherence. Secondary outcomes were exacerbation rate, dyspnoea, <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>\u2010specific and generic health status and smoking behaviour.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2010 to <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pril 2011, 734 patients were enrolled. Forty\u2010two patients (5.7%) were lost to follow\u2010up. At the end of the trial, inhalation score [mean estimated difference (\u0394),13.5%; 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>), 10.8\u201316.1; <jats:italic>P<\/jats:italic> &lt; 0.0001] and medication adherence (\u0394, 8.51%; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 4.63\u201312.4; <jats:italic>P<\/jats:italic> &lt; 0.0001) were significantly higher in the intervention group compared with the control group. In the intervention group, a significantly lower hospitalization rate was observed (9 <jats:italic>vs<\/jats:italic>. 35; rate ratio, 0.28; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.12\u20130.64; <jats:italic>P<\/jats:italic> = 0.003). No other significant between\u2010group differences were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pragmatic pharmacist care programmes improve the pharmacotherapeutic regimen in patients with <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> and could reduce hospitalization rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.12242","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:22:11Z","timestamp":1381544531000},"page":"756-766","source":"Crossref","is-referenced-by-count":129,"title":["Effectiveness of pharmaceutical care for patients with chronic obstructive pulmonary disease (<scp>PHARMACOP<\/scp>): a randomized controlled trial"],"prefix":"10.1111","volume":"77","author":[{"given":"Eline","family":"Tommelein","sequence":"first","affiliation":[{"name":"Pharmaceutical Care Unit Faculty of Pharmaceutical Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Els","family":"Mehuys","sequence":"additional","affiliation":[{"name":"Pharmaceutical Care Unit Faculty of Pharmaceutical Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Van Hees","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Els","family":"Adriaens","sequence":"additional","affiliation":[{"name":"Pharmaceutical Care Unit Faculty of Pharmaceutical Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Van Bortel","sequence":"additional","affiliation":[{"name":"Heymans Institute of Pharmacology, Faculty of Medicine and Health Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Christiaens","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Primary Health Care Faculty of Medicine and Health Sciences Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Van Tongelen","sequence":"additional","affiliation":[{"name":"Pharmaceutical Care Unit Faculty of Pharmaceutical Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Paul","family":"Remon","sequence":"additional","affiliation":[{"name":"Pharmaceutical Care Unit Faculty of Pharmaceutical Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Boussery","sequence":"additional","affiliation":[{"name":"Pharmaceutical Care Unit Faculty of Pharmaceutical Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Brusselle","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Ghent University Hospital  Ghent Belgium"},{"name":"Departments of Epidemiology and Respiratory Medicine Erasmus MC  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,22]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Global strategy for the diagnosis management and prevention of chronic obstructive pulmonary disease. 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