{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:12:57Z","timestamp":1790698377635,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T00:00:00Z","timestamp":1398124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2014,5]]},"abstract":"\n Aims<\/jats:title>\n \n A drug\u2010related problem (\n DRP<\/jats:styled-content>\n ) is \u2018an event or circumstance involving drug therapy that actually or potentially interferes with the desired health outcome\u2019. The extent and characteristics of\n DRPs<\/jats:styled-content>\n in children in\n H<\/jats:styled-content>\n ong\n K<\/jats:styled-content>\n ong are unknown. The aim of this study was to determine the epidemiology of and identify risk factors for\n DRPs<\/jats:styled-content>\n in hospitalized children in\n H<\/jats:styled-content>\n ong\n K<\/jats:styled-content>\n ong.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was a prospective cohort study in children aged 0\u201318 years who were admitted to a medical ward, paediatric intensive care unit or neonatal intensive care unit of seven\n H<\/jats:styled-content>\n ong\n K<\/jats:styled-content>\n ong hospitals, during a 3 month period. Patients' charts, medical records and laboratory data were reviewed daily to identify\n DRPs<\/jats:styled-content>\n ; their preventability and severity were assessed. Logistic regression was used to analyse potential risk factors associated with the incidence of\n DRPs<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Three hundred and twenty\u2010nine children (median age, 2 years; interquartile range, 0 months to 9 years) were included. In total, 82\n DRPs<\/jats:styled-content>\n were experienced by 69 patients. The overall incidence of\n DRPs<\/jats:styled-content>\n was 21.0% (95% confidence interval, 16.7\u201325.8%). The incidence was higher in neonatal and paediatric intensive care units than medical wards. Dosing problems were the most frequently reported\n DRPs<\/jats:styled-content>\n (\n n<\/jats:italic>\n = 35; 42.7%), followed by drug choice problems (\n n<\/jats:italic>\n = 19; 23.2%) and adverse drug reactions (\n n<\/jats:italic>\n = 11; 13.4%). Sixty\u2010seven (81.7%)\n DRP<\/jats:styled-content>\n cases were assessed as preventable, 42 (51.2%) as minor and 40 (48.8%) as moderate. The number of prescribed drugs and \u2018certain infectious and parasitic diseases\u2019 were potential risk factors for occurrence of\n DRPs<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Drug\u2010related problems were common in hospitalized children in this study in\n H<\/jats:styled-content>\n ong\n K<\/jats:styled-content>\n ong; the most frequent were dosing and drug choice problems, and the majority of them were preventable. Polypharmacy and \u2018certain infectious and parasitic diseases\u2019 were potential risk factors.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bcp.12270","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T23:34:45Z","timestamp":1383003285000},"page":"873-879","source":"Crossref","is-referenced-by-count":61,"title":["Epidemiology and potential risk factors of drug\u2010related problems in\n H<\/scp>\n ong\n K<\/scp>\n ong paediatric wards"],"prefix":"10.1111","volume":"77","author":[{"given":"Asia N.","family":"Rashed","sequence":"first","affiliation":[{"name":"Centre for Paediatric Pharmacy Research UCL School of Pharmacy London UK"},{"name":"Institute of Pharmaceutical Science King's Health Partners King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Wilton","sequence":"additional","affiliation":[{"name":"Centre for Paediatric Pharmacy Research UCL School of Pharmacy London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles C. H.","family":"Lo","sequence":"additional","affiliation":[{"name":"Hospital Authority Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin Y. S.","family":"Kwong","sequence":"additional","affiliation":[{"name":"Hospital Authority Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Leung","sequence":"additional","affiliation":[{"name":"Hospital Authority Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian C. K.","family":"Wong","sequence":"additional","affiliation":[{"name":"Centre for Paediatric Pharmacy Research UCL School of Pharmacy London UK"},{"name":"Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy (DPP) Li Ka Shing Faculty of Medicine, The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,22]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Pharmaceutical Care Network Europe (PCNE).2006) Available athttp:\/\/www.pcne.org\/(last accessed August 2013)."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-012-1302-x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-006-9020-z"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2149-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2003.02052.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-013-9758-z"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001786-200307000-00003"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/106002809302700702"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/56.1.57"},{"key":"e_1_2_9_11_1","first-page":"538","article-title":"Focusing on the preventability of adverse drug reactions","volume":"27","author":"Schumock GT","year":"1992","journal-title":"Hosp Pharm"},{"key":"e_1_2_9_12_1","unstructured":"WHO Anatomic Therapeutic Chemical Classification. Available athttp:\/\/www.whocc.no\/atc_ddd_index\/(last accessed August2013)."},{"key":"e_1_2_9_13_1","unstructured":"International Classification of Diseases Version 10. Available athttp:\/\/www.who.int\/classifications\/icd\/en\/(accessed August2013)."},{"key":"e_1_2_9_14_1","unstructured":"ICH Guideline:International Conference on Harmonisation (ICH) Guideline. E11: Clinical Investigation of Medicinal Products in the Paediatric Population. (2001) European Medicines Agency for the Evaluation of Medicinal Products (EMEA) London UK. Available athttp:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Scientific_guideline\/2009\/09\/WC500002926.pdf(last accessed August 2013)."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.21.2553"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010011\u20101183\u20104"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2165\/11597920-000000000-00000"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.127761"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.2.254"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2003.08.003"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcp.12270","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.12270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T10:45:08Z","timestamp":1696329908000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.12270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,22]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/bcp.12270"],"URL":"https:\/\/doi.org\/10.1111\/bcp.12270","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,22]]}}}