{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:00Z","timestamp":1787013900113,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T00:00:00Z","timestamp":1398124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2014,5]]},"abstract":"\n Aims<\/jats:title>\n \n To investigate the\n QT<\/jats:styled-content>\n interval after high dose droperidol using continuous 12\u2010lead Holter recordings.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was a prospective study of patients given droperidol with a continuous Holter recording. Patients were recruited from the\n DORM II<\/jats:styled-content>\n study which included patients with aggression presenting to the emergency department. Patients initially received 10\u2009mg droperidol as part of a standardized sedation protocol. An additional 10\u2009mg dose was given after 15\u2009min if required and further doses at the clinical toxicologist's discretion. Continuous 12\u2010lead Holter recordings were obtained for 2\u201324\u2009h utilizing high resolution digital recordings with automated\n QT<\/jats:styled-content>\n interval measurement. Electrocardiograms were extracted hourly from Holter recordings. The\n QT<\/jats:styled-content>\n interval was plotted against heart rate (\n HR<\/jats:styled-content>\n ) on the\n QT<\/jats:styled-content>\n nomogram to determine if it was abnormal.\n \n QT\n c<\/jats:sub>\n F\n <\/jats:styled-content>\n (\n F<\/jats:styled-content>\n ridericia's\n HR<\/jats:styled-content>\n correction) was calculated and >500\u2009ms was defined as abnormal.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Forty\u2010six patients had Holter recordings after 10\u201340\u2009mg droperidol and 316\n QT<\/jats:styled-content>\n \u2013\n HR<\/jats:styled-content>\n pairs were included. There were 32 abnormal\n QT<\/jats:styled-content>\n measurements in four patients, three given 10\u2009mg and one 20\u2009mg. In three of the four patients\n \n QT\n c<\/jats:sub>\n F\n <\/jats:styled-content>\n >500\u2009ms but only in one taking methadone was the timing of\n \n QT\n c<\/jats:sub>\n F\n <\/jats:styled-content>\n >500\u2009ms consistent with droperidol dosing. Of the three other patients, one took amphetamines, one still had\n QT<\/jats:styled-content>\n prolongation 24\u2009h after droperidol and one took a lamotrigine overdose. No patient given >30\u2009mg had a prolonged\n QT<\/jats:styled-content>\n . There were no arrhythmias.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n QT<\/jats:styled-content>\n prolongation was observed with high dose droperidol. However, there was little evidence supporting droperidol being the cause and\n QT<\/jats:styled-content>\n prolongation was more likely due to pre\u2010existing conditions or other drugs.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bcp.12272","type":"journal-article","created":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T03:20:50Z","timestamp":1383103250000},"page":"880-886","source":"Crossref","is-referenced-by-count":32,"title":["High dose droperidol and\n QT<\/scp>\n prolongation: analysis of continuous 12\u2010lead recordings"],"prefix":"10.1111","volume":"77","author":[{"given":"Leonie","family":"Calver","sequence":"first","affiliation":[{"name":"School of Medicine and Public Health University of Newcastle Newcastle New South Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey K.","family":"Isbister","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health University of Newcastle Newcastle New South 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