{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:39:55Z","timestamp":1770439195063,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,7,21]],"date-time":"2014-07-21T00:00:00Z","timestamp":1405900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"European Commission FP7","award":["HEALTH F2 2009 223062"],"award-info":[{"award-number":["HEALTH F2 2009 223062"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Adherence to the generally complex regimen of coumarin derivatives is vital in order to keep patients in the adequate <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nternational <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ormalized <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>atio range. Patients' beliefs about medicines are associated with the level of therapy adherence. Our first aim was to assess beliefs about coumarins. Secondly, we compared the beliefs about coumarins with the beliefs about other cardiovascular drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>eliefs about <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edicines <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uestionnaire was used to assess medication beliefs. The questionnaire was completed by new users of coumarins indicated for venous thromboembolism or atrial fibrillation. A necessity score and a concerns score were calculated for all patients. The analyses were repeated for users of antihypertensive drugs or statins (not using coumarins).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred and twenty patients were included in the analysis of the beliefs about coumarins. The mean necessity score was 15.3, the concerns score 12.3 and the necessity\u2013concerns differential 3.0. Patients with venous thromboembolism (<jats:italic>n<\/jats:italic> = 71) had higher necessity scores than patients with atrial fibrillation (<jats:italic>n<\/jats:italic> = 249; 16.8 <jats:italic>vs<\/jats:italic>. 14.9, <jats:italic>P<\/jats:italic> &lt; 0.001). The mean necessity score in 493 users of other cardiovascular drugs was 16.1, the concerns score 13.5 and the necessity\u2013concerns differential 2.6. The necessity score was higher in chronic cardiovascular drug users (<jats:italic>n<\/jats:italic> = 192) than in new users (<jats:italic>n<\/jats:italic> = 301; 17.9 <jats:italic>vs<\/jats:italic>. 14.9, <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Coumarin users score higher on the necessity scale than on the concerns scale, which is also the case in users of other cardiovascular drugs. Patients with atrial fibrillation have a less positive attitude towards these drugs than patients with venous thromboembolism, and could therefore benefit more from specific attention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.12346","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T12:23:37Z","timestamp":1392639817000},"page":"422-429","source":"Crossref","is-referenced-by-count":8,"title":["Beliefs about medicines in <scp>D<\/scp>utch acenocoumarol and phenprocoumon users"],"prefix":"10.1111","volume":"78","author":[{"given":"Talitha I.","family":"Verhoef","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology and Clinical Pharmacology Utrecht University  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Ken","family":"Redekop","sequence":"additional","affiliation":[{"name":"Institute for Medical Technology Assessment Erasmus University  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel L.","family":"Bouvy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology and Clinical Pharmacology Utrecht University  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda","family":"Dorenbos","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology and Clinical Pharmacology Utrecht University  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zamiera","family":"Karwar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology and Clinical Pharmacology Utrecht University  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rianne M. F.","family":"van Schie","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology and Clinical Pharmacology Utrecht University  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthonius","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology and Clinical Pharmacology Utrecht University  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke\u2010Hilse","family":"Maitland\u2010van der Zee","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology and Clinical Pharmacology Utrecht University  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"EU\u2010PACT group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2007.05.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2008.01279.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2753.2010.01589.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh587"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2007.07.016"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/08870449908407311"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0670"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.12.199"},{"key":"e_1_2_9_10_1","first-page":"659","article-title":"Persistence on warfarin in patients with atrial fibrillation: experience in Australia 2006\u20132009","volume":"42","author":"Simons LA","year":"2013","journal-title":"Aust Fam Physician"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.09.125"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2011.04.004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1370\/afm.238"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1K497"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12086"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1E464"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcp.12346","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.12346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T15:59:57Z","timestamp":1696348797000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.12346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,21]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/bcp.12346"],"URL":"https:\/\/doi.org\/10.1111\/bcp.12346","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,21]]}}}