{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:12:47Z","timestamp":1778026367455,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T00:00:00Z","timestamp":1421712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to compare the performances of contemporary cystatin <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">Cys<\/jats:styled-content>)\u2010based <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> equations, and the creatinine only Chronic Kidney Disease Epidemiology Collaboration (<jats:styled-content style=\"fixed-case\">CKD\u2010EPI<\/jats:styled-content>) equation for predicting gentamicin clearance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The bias and imprecision of the <jats:styled-content style=\"fixed-case\">CKD\u2010EPI<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CKD\u2010EPI<\/jats:styled-content>_<jats:styled-content style=\"fixed-case\">Cys<\/jats:styled-content> and creatinine\u2010cystatin <jats:styled-content style=\"fixed-case\">C CKD\u2010EPI<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CKD\u2010EPI<\/jats:styled-content>_<jats:styled-content style=\"fixed-case\">CrCys<\/jats:styled-content>) equations for predicting gentamicin clearances, were assessed in 260 patients treated with gentamicin during 2012\u20132013. The creatinine\u2010cystatin <jats:styled-content style=\"fixed-case\">C B<\/jats:styled-content>erlin Initiative Study equation (<jats:styled-content style=\"fixed-case\">BIS<\/jats:styled-content>_<jats:styled-content style=\"fixed-case\">CrCys<\/jats:styled-content>) was examined in the \u226570 year subgroup. The reference gentamicin clearance was calculated using post\u2010dose plasma concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CKD\u2010EPI<\/jats:styled-content>_<jats:styled-content style=\"fixed-case\">CrCys<\/jats:styled-content> equation had the highest percentage of estimates within 30% of the reference gentamicin clearance (70%, <jats:italic>P<\/jats:italic> = 0.003) and lowest root mean square error (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) of 29 (25, 23) ml\u2009min<jats:sup>\u22121<\/jats:sup> of the three equations for the entire cohort. There was no significant improvement in the performances of the equations with the exclusion of 41 patients with abnormal thyroid function tests or steroid co\u2010prescription at the time of the index gentamicin dose. Of the remaining 219 patients, adjustment for individual <jats:styled-content style=\"fixed-case\">BSA<\/jats:styled-content> improved the performances of all <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> equations (<jats:italic>P<\/jats:italic> \u2264 0.003) in those with body mass indices (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) &lt;18.5 or \u226530\u2009kg\u2009m<jats:sup>\u22122<\/jats:sup>, but not those with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> 18.5\u201329.9\u2009kg\u2009m<jats:sup>\u22122<\/jats:sup>. There was no advantage of the <jats:styled-content style=\"fixed-case\">BIS<\/jats:styled-content>_<jats:styled-content style=\"fixed-case\">CrCys<\/jats:styled-content> over the <jats:styled-content style=\"fixed-case\">CKD\u2010EPI<\/jats:styled-content>_<jats:styled-content style=\"fixed-case\">CrCys<\/jats:styled-content> equation in the \u226570 year subgroup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CKD\u2010EPI<\/jats:styled-content>_<jats:styled-content style=\"fixed-case\">CrCys<\/jats:styled-content> equation provided the best estimate of gentamicin clearance. If used for guiding gentamicin dosing, the results from <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> equations should be adjusted for individual <jats:styled-content style=\"fixed-case\">BSA<\/jats:styled-content> at the extremes of body size.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.12501","type":"journal-article","created":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T09:48:32Z","timestamp":1409046512000},"page":"268-277","source":"Crossref","is-referenced-by-count":15,"title":["The performance of contemporary cystatin <scp>C<\/scp>\u2010based <scp>GFR<\/scp> equations in predicting gentamicin clearance"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5470-5191","authenticated-orcid":false,"given":"Paul K. L.","family":"Chin","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Christchurch Hospital  Christchurch"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice S. 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