{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:02Z","timestamp":1787013902872,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T00:00:00Z","timestamp":1427068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2015,4]]},"abstract":"\n Aim<\/jats:title>\n \n The incidence of adverse drug events (\n ADEs<\/jats:styled-content>\n ) in surgical and non\u2010surgical patients may differ. This individual patient data meta\u2010analysis (\n IPDMA<\/jats:styled-content>\n ) identifies patient characteristics and types of medication most associated with patients experiencing\n ADEs<\/jats:styled-content>\n and suggests target areas for reducing harm and implementing focused interventions.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Authors of eligible studies on preventable\n ADEs<\/jats:styled-content>\n (\n pADEs<\/jats:styled-content>\n ) were approached for collaboration. For assessment of differences among (non\u2010)surgical patients and identification of associated factors descriptive statistics,\n P<\/jats:styled-content>\n earson chi\u2010square, Poisson and logistic regression analyses were performed. For identification of high risk drugs (\n HRDs<\/jats:styled-content>\n ), a model was developed based on frequency, severity and preventability of medication related to\n ADEs<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Included were 5367 patients from four studies. Patients aged \u2265 77 years experienced more\n ADEs<\/jats:styled-content>\n and\n pADEs<\/jats:styled-content>\n compared with patients aged \u2264 52 years (odds ratios (\n OR<\/jats:styled-content>\n ) 2.12 (95%\n CI<\/jats:styled-content>\n 1.70, 2.65) and 2.55 (95%\n CI<\/jats:styled-content>\n 1.70, 3.84), respectively, both\n P<\/jats:italic>\n < 0.05). Polypharmacy on admission also increased the risk of\n ADEs<\/jats:styled-content>\n (\n OR<\/jats:styled-content>\n 1.21 (95%\n CI<\/jats:styled-content>\n 1.03, 1.44),\n P<\/jats:italic>\n < 0.05) and\n pADEs<\/jats:styled-content>\n (\n OR<\/jats:styled-content>\n 1.85 (95%\n CI<\/jats:styled-content>\n 1.34, 2.56),\n P<\/jats:italic>\n < 0.05).\n pADEs<\/jats:styled-content>\n were associated with more severe harm than non\u2010preventable\n ADEs<\/jats:styled-content>\n (54%\n vs<\/jats:italic>\n . 32%,\n P<\/jats:italic>\n < 0.05). The top five\n HRDs<\/jats:styled-content>\n were antibiotics, sedatives, anticoagulants, diuretics and antihypertensives. Events associated with\n HRDs<\/jats:styled-content>\n included diarrhoea or constipation, abnormal liver function test and central nervous system events. Most\n pADEs<\/jats:styled-content>\n resulted from prescribing errors (90%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Elderly patients with polypharmacy on admission and receiving antibiotics, sedatives, anticoagulants, diuretics or antihypertensives were more prone to experiencing\n ADEs<\/jats:styled-content>\n . Efficiency in prevention of\n ADEs<\/jats:styled-content>\n may be improved by targeted vigilance systems for alertness of physicians and pharmacists.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bcp.12504","type":"journal-article","created":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T06:02:02Z","timestamp":1410242522000},"page":"548-557","source":"Crossref","is-referenced-by-count":26,"title":["An individual patient data meta\u2010analysis on factors associated with adverse drug events in surgical and non\u2010surgical inpatients"],"prefix":"10.1111","volume":"79","author":[{"given":"Eveline B.","family":"Boeker","sequence":"first","affiliation":[{"name":"Department of Surgery Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Ram","sequence":"additional","affiliation":[{"name":"Department of Surgery Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna E.","family":"Klopotowska","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmacy Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmacy Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montse Tuset","family":"Creus","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmacy Hospital Clinic Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L.","family":"de Andr\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmacy Hospital Clinic Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mio","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine Hyogo College of Medicine Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine Hyogo College of Medicine Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marja A.","family":"Boermeester","sequence":"additional","affiliation":[{"name":"Department of Surgery Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel G. W.","family":"Dijkgraaf","sequence":"additional","affiliation":[{"name":"Clinical Research Unit Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,23]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"To Err Is Human: Building A Safer Health System","author":"Kohn LT","year":"1999"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2009001500003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2006.02698.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200730050-00003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa0911535"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/qshc.2006.019273"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/qshc.2005.015107"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2000.00145.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-014-9941-x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-013-9797-5"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-012-1316-4"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/17.3.261"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(02)00411-0"},{"key":"e_1_2_9_15_1","unstructured":"National Cancer Institute.Common Terminology Criteria for Adverse Events v.3.0and v.4.0 (CTCAE). 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