{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:45:00Z","timestamp":1788871500834,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T00:00:00Z","timestamp":1421712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Psychiatric Research Council of Southern Denmark"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      Our objective was to investigate the steady\u2010state pharmacokinetic and pharmacodynamic interaction between the antidepressive herbal medicine\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      t\n                      <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>\n                      ohn's wort and the antidiabetic drug metformin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed an open cross\u2010over study in 20 healthy male subjects, who received 1\u2009g of metformin twice daily for 1 week with and without 21 days of preceding and concomitant treatment with\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      t\n                      <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>\n                      ohn's wort. The pharmacokinetics of metformin was determined, and a 2\u2009h oral glucose tolerance test was performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      t\n                      <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>\n                      ohn's wort decreased the renal clearance of metformin but did not affect any other metformin pharmacokinetic parameter. The addition of\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      t\n                      <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>\n                      ohn's wort decreased the area under the glucose concentration\u2013time curve [702 (95% confidence interval, 643\u2013761)\n                      <jats:italic>vs<\/jats:italic>\n                      . 629\u2009min*mmol\/L (95% confidence interval, 568\u2013690),\n                      <jats:italic>P<\/jats:italic>\n                      = 0.003], and this effect was caused by a statistically significant increase in the acute insulin response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      t\n                      <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>\n                      ohn's wort improves glucose tolerance by enhancing insulin secretion independently of insulin sensitivity in healthy male subjects taking metformin.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcp.12510","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T00:46:57Z","timestamp":1410828417000},"page":"298-306","source":"Crossref","is-referenced-by-count":33,"title":["Intake of\n                    <scp>S<\/scp>\n                    t\n                    <scp>J<\/scp>\n                    ohn's wort improves the glucose tolerance in healthy subjects who ingest metformin compared with metformin alone"],"prefix":"10.1111","volume":"79","author":[{"given":"Tore Bjerregaard","family":"Stage","sequence":"first","affiliation":[{"name":"Research Unit of Clinical Pharmacology Institute of Public Health University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus Steen","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Research Unit of Clinical Pharmacology Institute of Public Health University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Damkier","sequence":"additional","affiliation":[{"name":"Research Unit of Clinical Pharmacology Institute of Public Health University of Southern Denmark Odense Denmark"},{"name":"Department of Clinical Biochemistry and Pharmacology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette Marie Hougaard","family":"Christensen","sequence":"additional","affiliation":[{"name":"Research Unit of Clinical Pharmacology Institute of Public Health University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Feddersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Pharmacology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Teilmann","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Odense Mental Health Services in the Region of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"H\u00f8jlund","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Br\u00f8sen","sequence":"additional","affiliation":[{"name":"Research Unit of Clinical Pharmacology Institute of Public Health University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,20]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"WHO.Diabetes. 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