{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T17:22:17Z","timestamp":1749316937758,"version":"3.37.3"},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T00:00:00Z","timestamp":1424390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the safety of our clinical practice using off\u2010label intravenous metoprolol to facilitate computed tomographic (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) coronary angiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of scan reports and hospital admissions data was conducted to identify adverse events occurring following <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> coronary angiography in patients who had received intravenous metoprolol prior to the scan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3098 patients were included, of whom 1871 received intravenous metoprolol. Nine hundred and one patients received more than 15\u2009mg and 129 patients received metoprolol despite a resting heart rate &lt;65 beats min<jats:sup>\u22121<\/jats:sup>. There was a single adverse incident, comprising transient loss of consciousness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of intravenous metoprolol to facilitate cardiac <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scanning appears safe. Dose limits recommended for other indications, generally in acutely unwell patients, may not need to be as stringent in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.12516","type":"journal-article","created":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T03:48:54Z","timestamp":1410925734000},"page":"533-536","source":"Crossref","is-referenced-by-count":8,"title":["Safety of intravenous \u03b2\u2010adrenoceptor blockers for computed tomographic coronary angiography"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6173-7263","authenticated-orcid":false,"given":"Benjamin","family":"Clayton","sequence":"first","affiliation":[{"name":"Cardiology Department Derriford Hospital  Plymouth PL6\u20098DH UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikram","family":"Raju","sequence":"additional","affiliation":[{"name":"Radiology Department Derriford Hospital  Plymouth PL6\u20098DH UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl","family":"Roobottom","sequence":"additional","affiliation":[{"name":"Radiology Department Derriford Hospital  Plymouth PL6\u20098DH UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gareth","family":"Morgan\u2010Hughes","sequence":"additional","affiliation":[{"name":"Cardiology Department Derriford Hospital  Plymouth PL6\u20098DH UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2010.05.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2009.03.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2239-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.04.1944"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10100140"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.10.058"},{"key":"e_1_2_9_8_1","unstructured":"AstraZenica.Summary of Product Characteristics \u2013 Betaloc IV Injection.2013. Available athttp:\/\/www.mhra.gov.uk\/home\/groups\/spcpil\/documents\/spcpil\/con1395381956177.pdf(last accessed 7 May 2014)."}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcp.12516","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.12516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T22:04:11Z","timestamp":1694469851000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.12516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,20]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/bcp.12516"],"URL":"https:\/\/doi.org\/10.1111\/bcp.12516","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"type":"print","value":"0306-5251"},{"type":"electronic","value":"1365-2125"}],"subject":[],"published":{"date-parts":[[2015,2,20]]}}}