{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:25:19Z","timestamp":1786926319763,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T00:00:00Z","timestamp":1427068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Drugs used for postoperative nausea and vomiting prophylaxis are believed to provoke torsadogenic changes in cardiac repolarization. The aim of this study was to assess the effect of small doses of droperidol on the parameters of cardiac repolarization, including the <jats:styled-content style=\"fixed-case\">QT<jats:sub>c<\/jats:sub><\/jats:styled-content> interval and transmural dispersion of repolarization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 75 patients were randomly allocated to receive 0.625 or 1.25\u2009mg droperidol or 8\u2009mg ondansetron. The <jats:styled-content style=\"fixed-case\">QT<jats:sub>c<\/jats:sub><\/jats:styled-content> interval was calculated using <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>azett's formula and the <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ramingham correction. The transmural dispersion of repolarization was determined as T<jats:sub>peak<\/jats:sub>\u2013T<jats:sub>end<\/jats:sub> time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Transient <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content> prolongation, corrected with both formulae, followed 1.25\u2009mg of droperidol 10\u2009min after administration. No change in the <jats:styled-content style=\"fixed-case\">QT<jats:sub>c<\/jats:sub><\/jats:styled-content> value was observed in the other groups. When corrected with Bazett's formula, <jats:styled-content style=\"fixed-case\">QT<jats:sub>c<\/jats:sub><\/jats:styled-content> was prolonged above 480 ms in two patients receiving 1.25\u2009mg droperidol (at the 10<jats:sup>th<\/jats:sup> and 20<jats:sup>th<\/jats:sup> minute of the study) and in one receiving ondansetron. No patients developed a <jats:styled-content style=\"fixed-case\">QT<jats:sub>c<\/jats:sub>B<\/jats:styled-content> prolongation over 500 ms. No increase above 480 ms was observed relative to the Framingham correction method. There were no significant differences in the T<jats:sub>peak<\/jats:sub>\u2013T<jats:sub>end<\/jats:sub> time either between or within the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In men without cardiovascular disorders small doses (1.25\u2009mg) of droperidol prophylaxis induced transient <jats:styled-content style=\"fixed-case\">QT<jats:sub>c<\/jats:sub><\/jats:styled-content> prolongation without changes in transmural dispersion of repolarization. The apparently low risk of the drug applies only in low risk male patients with a low pro\u2010<jats:styled-content style=\"fixed-case\">QT<jats:sub>c<\/jats:sub><\/jats:styled-content> score.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.12527","type":"journal-article","created":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T10:43:03Z","timestamp":1412764983000},"page":"669-676","source":"Crossref","is-referenced-by-count":20,"title":["Small doses of droperidol do not present relevant torsadogenic actions: a double\u2010blind, ondansetron\u2010controlled study"],"prefix":"10.1111","volume":"79","author":[{"given":"Krzysztof","family":"Tracz","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Therapy Copernicus Medical Centre  Gda\u0144sk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rados\u0142aw","family":"Owczuk","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Therapy Medical University of Gda\u0144sk  Gda\u0144sk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2009.06124.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000063923.87560.37"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2007.08.003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1R156"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31816ba463"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181684e6a"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5603\/KP.2013.0046"},{"issue":"2","key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/j.hrthm.2004.09.011","article-title":"Role of transmural dispersion of repolarization in the genesis of drug\u2010induced torsades de pointes","volume":"2","author":"Antzelevitch C","year":"2005","journal-title":"Heart Rhythm"},{"key":"e_1_2_8_10_1","first-page":"1154","article-title":"Regional and transmural dispersion of repolarisation in patients with Emery\u2010Dreifuss muscular dystrophy","volume":"70","author":"Nigro G","year":"2012","journal-title":"Kardiol Pol"},{"key":"e_1_2_8_11_1","first-page":"483","article-title":"The influence of anesthesia on cardiac repolarization","volume":"78","author":"Owczuk R","year":"2012","journal-title":"Minerva Anestesiol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2002.460801.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.01.013"},{"key":"e_1_2_8_14_1","unstructured":"International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use.2005ICH Harmonised Tripartite Guideline. 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