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Some studies have shown that statins are able to modulate inflammation and alveolar bone loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In order to evaluate whether statins could influence periodontal treatment, improving the clinical and radiographic parameters in chronic periodontitis, a systematic review was conducted in the databases\n                      <jats:styled-content style=\"fixed-case\">PUBMED<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">BIREME<\/jats:styled-content>\n                      , searching for articles in\n                      <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\n                      nglish and\n                      <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      ortuguese, published between the years 2004 and 2014, using the combined keywords statin, periodontal disease, periodontitis and alveolar bone. Studies regarding the treatment of chronic periodontitis in humans, blind or double\u2010blind, retrospective cohort or randomized controlled trials that used statins topically or systemically were selected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Statins have important anti\u2010inflammatory and immune effects, reducing levels of\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      \u2010reactive protein and matrix metalloproteinases and their intermediate products, such as tumour necrosis factor\u2010\u03b1, and are also able to inhibit the adhesion and extravasation of leukocytes, which block the co\u2010stimulation of\n                      <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                      cells. Statins reduce bone resorption by inhibiting osteoclast formation and lead to increased apoptosis of these cells. The effect of statins on bone formation is related to the increased gene expression of bone morphogenetic protein in osteoblasts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although we found biological mechanisms and clinical results that show lower alveolar bone loss and reduction of clinical signs of inflammation, further studies are needed to evaluate the clinical applicability of statins in the routine treatment of chronic periodontitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcp.12564","type":"journal-article","created":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T22:41:51Z","timestamp":1417473711000},"page":"877-885","source":"Crossref","is-referenced-by-count":48,"title":["Pleiotropic effects of statins on the treatment of chronic periodontitis \u2013 a systematic 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