{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T17:21:47Z","timestamp":1771953707298,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T00:00:00Z","timestamp":1432252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of the study was to analyze the prescribing pattern of both newer and older AEDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population of almost 150 000 individuals registered with 123 general practitioners was included in this study. Patients who received at least one AED prescription over 2005\u20132011 were identified. The 1 year prevalence and cumulative incidence of AED use, by drug class and individual drug, were calculated over the study period. Potential predictors of starting therapy with newer AEDs were also investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of use per 1000 inhabitants of older AEDs increased from 10.7 (95% CI10.1, 11.2) in 2005 to 13.0 (95% CI12.4, 13.6) in 2011, while the incidence remained stable. Newer AED incidence decreased from 9.4 (95% CI 8.9, 9.9) in 2005 to 7.0 (95% CI 6.6, 7.5) in 2011, with a peak of 15.5 (95% CI 14.8, 16.1) in 2006. Phenobarbital and valproic acid were the most commonly prescribed AEDs as starting therapy for epilepsy. Gabapentin and pregabalin accounted for most new pain\u2010related prescriptions, while valproic acid and lamotrigine were increasingly used for mood disorders. Female gender (OR 1.36, 95% CI 1.20, 1.53), age ranging between 45\u201354 years (OR 1.39, 95% CI 1.16, 1.66) and pain as an indication (OR 16.7, 95% CI, 13.1, 21.2) were associated with newer AEDs starting therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Older AEDs were mainly used for epileptic and mood disorders, while newer drugs were preferred for neuropathic pain. Gender, age, indication of use and year of starting therapy influenced the choice of AED type. The decrease of newer AED use during 2007 is probably related to the restricted reimbursement criteria for gabapentin and pregabalin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.12577","type":"journal-article","created":{"date-parts":[[2014,12,31]],"date-time":"2014-12-31T06:15:52Z","timestamp":1420006552000},"page":"1010-1019","source":"Crossref","is-referenced-by-count":33,"title":["Indications of newer and older anti\u2010epileptic drug use: findings from a southern Italian general practice setting from 2005\u20132011"],"prefix":"10.1111","volume":"79","author":[{"given":"Domenico","family":"Italiano","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Messina Messina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Capuano","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Pharmacology Section, Campania Regional Center of Pharmacovigilance and Pharmacoepidemiology Second University of Naples Naples"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Alibrandi","sequence":"additional","affiliation":[{"name":"Department of Economics, Business, Environmental Science and Quantitative Methodologies University of Messina Messina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosarita","family":"Ferrara","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Messina Messina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Cannata","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Messina Messina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Trifir\u00f2","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Messina Messina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Sultana","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Messina Messina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Ferrajolo","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Pharmacology Section, Campania Regional Center of Pharmacovigilance and Pharmacoepidemiology Second University of Naples Naples"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Tari","sequence":"additional","affiliation":[{"name":"Caserta Local Health Service Caserta Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele Ugo","family":"Tari","sequence":"additional","affiliation":[{"name":"Caserta Local Health Service Caserta Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margherita","family":"Perrotta","sequence":"additional","affiliation":[{"name":"Caserta Local Health Service Caserta Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Pagliaro","sequence":"additional","affiliation":[{"name":"Caserta Local Health Service Caserta Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concita","family":"Rafaniello","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Pharmacology Section, Campania Regional Center of Pharmacovigilance and Pharmacoepidemiology Second University of Naples Naples"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Spina","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Messina Messina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Arcoraci","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Messina Messina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12074"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2006.00639.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-008-0480-z"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01268.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2001.00197.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03619.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2009.03.002"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12557"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.01970.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1684\/j.1950-6945.2004.tb00053.x","article-title":"Antiepileptic drugs: indications other than epilepsy","volume":"6","author":"Spina E","year":"2004","journal-title":"Epileptic Disord"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03712.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2001.00251.x"},{"key":"e_1_2_9_14_1","unstructured":"AIFA (Agenzia Italiana del Farmaco).Le note AIFA 2006\u20132007 per l'uso appropriato dei farmaci.2007. Available athttp:\/\/www.agenziafarmaco.gov.it\/sites\/default\/files\/Note_AIFA_testo_06\u201007.pdf(last accessed 25 April 2014)."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/21.3.299"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-005-0972-z"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01486.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23526"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-007-0459-1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1303"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2006.02687.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01522.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2007.10.010"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1871"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2011.02.012"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2011.05.003"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181cbcd5c"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2012.04.014"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1079"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2009.07.005"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2009.04.026"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000313157.15089.e6"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2005.00994.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2005.09.031"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2004.52115.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjopharm.2010.02.003"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-145-4-200608150-00008"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040134"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60857-0"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12025"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23147"},{"key":"e_1_2_9_42_1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1176\/ps.62.2.pss6202_0218","article-title":"Valproate prescription prevalence among women of childbearing age","volume":"62","author":"Wisner KL","year":"2011","journal-title":"Psychiatr Serv"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6509-3"},{"key":"e_1_2_9_44_1","unstructured":"DeanL.Comparing antiepileptics for bipolar disorder migraines fibromyalgia and chronic pain.2010. Available athttp:\/\/www.ncbi.nlm.nih.gov\/books\/NBK51072(last accessed 25 April 2014)."},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.120942"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-009-0641-8"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2004.05.008"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcp.12577","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.12577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T06:15:37Z","timestamp":1717654537000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.12577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,22]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/bcp.12577"],"URL":"https:\/\/doi.org\/10.1111\/bcp.12577","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,22]]}}}