{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:52:06Z","timestamp":1790391126880,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T00:00:00Z","timestamp":1432598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University Hospital of Angers","award":["Microtec Study"],"award-info":[{"award-number":["Microtec Study"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Current\u2010induced vasodilation (CIV) is an axon\u2010reflex response observed during monopolar current application such as iontophoresis. Cyclo\u2010oxygenase derivates (COD) participate in CIV and act as sensitizing agents at the anodal level. Mechanisms involved during cathodal current application (CCA) are partially unknown. In a randomized double\u2010blind crossover trial, we tested in 16 healthy subjects (i) the influence of the inter\u2010stimulation interval (I\u2010I) by comparing CIV following all\u2010at\u2010once 10 s CCA against 2 \u00d7 5 s CCA with intervals ranging from15 s\u201316 min and (ii) the participation of COD in CIV using 1 g aspirin or placebo intake.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Measurements were repeated 2 h and 14 days after treatment. Laser Doppler flowmetry assessed cutaneous blood flow, reported in multiples of baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Before treatment, peak vasodilation 10 min after the last current application (CVC<jats:sub>stim2<\/jats:sub>) increased compared with baseline whatever the I\u2010I. Increase in CVC<jats:sub>stim2<\/jats:sub> from baseline was greater for the 4 min (9.4 (5.3, 10.9) times; median (1<jats:sup>st<\/jats:sup> percentile, 3<jats:sup>rd<\/jats:sup> percentile)) and higher I\u2010Is compared with all\u2010at\u2010once delivery (3.0 (2.1, 4.3) times, <jats:italic>P<\/jats:italic> &lt; 0.05). The response was similar after placebo but aspirin abolished this vasodilation (increase by 1.2 (1.1, 1.3) times for all\u2010at\u2010once delivery and by 1.5 (1.3, 1.7) \u00b1 0.3 times for 4 min interval, 2 h after aspirin intake) that recovered after 14 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This confirms the participation of COD in CIV with CCA and their sensitizing action. This model can represent an attractive way to study the axon\u2010reflex and sensitizing function of COD in humans.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.12623","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T06:37:01Z","timestamp":1425623821000},"page":"185-192","source":"Crossref","is-referenced-by-count":4,"title":["Evidence for a vasomotor cyclo\u2010oxygenase dependent mechanism of sensitization at the cutaneous level"],"prefix":"10.1111","volume":"80","author":[{"given":"G.","family":"Mah\u00e9","sequence":"first","affiliation":[{"name":"Biologie Neurovasculaire et Mitochondriale Int\u00e9gr\u00e9e (BNMI) \u2010 Unit\u00e9 mixte UMR CNRS 6214 \/ INSERM U 1083 Facult\u00e9 de M\u00e9decine  Angers France"},{"name":"Laboratory of Vascular Investigations University Hospital of Angers  France"},{"name":"CHU Rennes Imagerie c\u0153ur\u2010vaisseaux  F\u201035033 Rennes France"},{"name":"INSERM Clinical Investigation Center CIC 1414  F\u201034043 Rennes France"},{"name":"Universit\u00e9 de Rennes 1  F\u201034043 Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Abraham","sequence":"additional","affiliation":[{"name":"Biologie Neurovasculaire et Mitochondriale Int\u00e9gr\u00e9e (BNMI) \u2010 Unit\u00e9 mixte UMR CNRS 6214 \/ INSERM U 1083 Facult\u00e9 de M\u00e9decine  Angers France"},{"name":"Laboratory of Vascular Investigations University Hospital of Angers  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Humeau\u2010Heurtier","sequence":"additional","affiliation":[{"name":"LARIS \u2010 Laboratoire Angevin de Recherche en Ing\u00e9nierie des Syst\u00e8mes Universit\u00e9 d'Angers  62 avenue Notre\u2010Dame du Lac 49000 Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Gascoin","sequence":"additional","affiliation":[{"name":"Laboratory of Vascular Investigations University Hospital of Angers  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Lefth\u00e9riotis","sequence":"additional","affiliation":[{"name":"Biologie Neurovasculaire et Mitochondriale Int\u00e9gr\u00e9e (BNMI) \u2010 Unit\u00e9 mixte UMR CNRS 6214 \/ INSERM U 1083 Facult\u00e9 de M\u00e9decine  Angers France"},{"name":"Laboratory of Vascular Investigations University Hospital of Angers  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1268-1694","authenticated-orcid":false,"given":"S.","family":"Durand","sequence":"additional","affiliation":[{"name":"Universit\u00e9 du Maine, EA 4334, Motricit\u00e9, Interactions, Performance LUNAM Universit\u00e9  Le Mans 72085 Cedex 9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.1997.2025"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.1995.1070"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000048994"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.267"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.013364"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00258.2005"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704868"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2013.04.005"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2014.04.001"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.111.970418"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000064515"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.78.6.3154"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00602.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01085.2012"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.143867"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061320"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmv.2013.11.004"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcp.12623","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.12623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T06:51:46Z","timestamp":1696315906000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.12623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,26]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/bcp.12623"],"URL":"https:\/\/doi.org\/10.1111\/bcp.12623","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,26]]}}}