{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T01:22:41Z","timestamp":1780536161664,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T00:00:00Z","timestamp":1438041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Erectile dysfunction is a common problem among patients with cardiovascular diseases and the influence of cardiovascular drugs is much debated. The aim of this study was to evaluate the short term potential for different cardiovascular drugs to affect the risk of being prescribed a drug against erectile dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We employed a symmetry analysis design and included all Danish male individuals born before 1950 who filled their first ever prescription for a cardiovascular drug and a 5\u2010phosphodiesterase inhibitor within a 6 month interval during 2002\u20132012. If the cardiovascular drug induces erectile dysfunction, this would manifest as a non\u2010symmetrical distribution of subjects being prescribed the cardiovascular drug first <jats:italic>vs<\/jats:italic>. persons following the opposite pattern. Furthermore, we calculated the number of patients needed to treat for one additional patient to be treated for erectile dysfunction (NNTH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 20 072 males with a median age of 64 years (IQR 60\u201370) who initiated a cardiovascular drug and a 5\u2010phosphodiesterase inhibitor within a 6 month interval. Sequence ratios showed minor asymmetry in prescription orders after adjustment for trends in prescribing. This asymmetry was most profound for thiazides (1.28, 95% CI 1.20, 1.38), calcium channel blockers (1.29, 95% CI 1.21, 1.38) and ACE inhibitors (1.29, 95% CI 1.21, 1.37), suggesting a small liability of these drugs to provoke erectile dysfunction. NNTH values were generally large, in the range of 330\u20136400, corresponding to small absolute effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study does not suggest that cardiovascular drugs strongly affect the risk of being prescribed a drug against erectile dysfunction on a short term basis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.12696","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T13:21:29Z","timestamp":1434720089000},"page":"1219-1223","source":"Crossref","is-referenced-by-count":19,"title":["Cardiovascular drugs and erectile dysfunction \u2013 a symmetry analysis"],"prefix":"10.1111","volume":"80","author":[{"given":"Lotte","family":"Rasmussen","sequence":"first","affiliation":[{"name":"Clinical Pharmacology, Department of Public Health University of Southern Denmark  DK\u20105000 Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Hallas","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, Department of Public Health University of Southern Denmark  DK\u20105000 Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth Gr\u00f8nkj\u00e6r","family":"Madsen","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, Department of Public Health University of Southern Denmark  DK\u20105000 Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Potteg\u00e5rd","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, Department of Public Health University of Southern Denmark  DK\u20105000 Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,28]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"47","article-title":"Sexual dysfunction as an obstacle to compliance with antihypertensive therapy","volume":"1","author":"Rosen RC","year":"1997","journal-title":"Blood Press Suppl"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12325"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2010.02563.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-013-0482-z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.21.7.676.34571"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901516"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/00001648-199609000-00005","article-title":"Evidence of depression provoked by cardiovascular medication: a prescription sequence symmetry analysis","volume":"7","author":"Hallas J.","year":"1996","journal-title":"Epidemiol Camb Mass"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-66"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1736"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3635"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7168.1309"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394717"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811399956"},{"key":"e_1_2_9_15_1","unstructured":"Statens Serum Institut[Internet]. 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