{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:57:52Z","timestamp":1778630272861,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T00:00:00Z","timestamp":1446595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Osteoarthritis (OA) is the most common musculoskeletal condition in the elderly population. However, no disease modifying drug exists for this disease. <jats:italic>In vivo<\/jats:italic> animal studies have suggested that thiazolidinediones (TZD) may be used as disease modifying osteoarthritis drugs (DMOADs). To our knowledge, this has not yet been examined in humans before. The aim was to determine the risk of total joint replacement (TJR) in patients using TZDs compared with diabetic patients using other antidiabetic drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population based case\u2013control study was performed using the Clinical Practice Research Datalink (CPRD). Cases (<jats:italic>n<\/jats:italic>\u00a0=\u00a094\u00a0609) were defined as patients &gt;18\u00a0years of age who had undergone total knee (TKR) or hip replacement (THR) between 2000 and 2012. Controls were matched by age, gender and practice\/surgery. Conditional logistic regression analyses were used to estimate the risk of TKR and THR with the use of TZDs in patients currently using one or more antidiabetic drugs. In order to determine effect with prolonged use, we also stratified TZD users by total number of prescriptions prior to surgery. We statistically adjusted our analyses for lifestyle factory, comorbidities and concomitant drug use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no difference in risk of TKR (OR 1.09, 95% CI 0.93, 1.27) and THR (OR 0.92, 95% CI 0.76, 1.10) when TZD users were compared with other AD users. Furthermore, we did not find an association with prolonged use of TZDs and TJR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite promising results from animal <jats:italic>in vivo<\/jats:italic> studies, this study did not find any evidence for a disease modifying osteoarthritic effect of TZDs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.12786","type":"journal-article","created":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T10:22:33Z","timestamp":1442398953000},"page":"370-378","source":"Crossref","is-referenced-by-count":19,"title":["Use of thiazolidinediones and the risk of elective hip or knee replacement: a population based case\u2013control study"],"prefix":"10.1111","volume":"81","author":[{"given":"Johannes T.H.","family":"Nielen","sequence":"first","affiliation":[{"name":"Department of Pharmacoepidemiology &amp; Clinical Pharmacology Utrecht University  Utrecht"},{"name":"Department of Epidemiology CAPHRI School for Public Health and Primary Care, Maastricht University  Maastricht"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Pharmacoepidemiology &amp; Clinical Pharmacology Utrecht University  Utrecht"},{"name":"Department of Clinical Pharmacy and Toxicology Maastricht University Medical Center  Maastricht"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter C.","family":"Dagnelie","sequence":"additional","affiliation":[{"name":"Department of Epidemiology CAPHRI School for Public Health and Primary Care, and CARIM School for Cardiovascular Diseases, Maastricht University  Maastricht"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart J.F.","family":"van den Bemt","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Sint Maartenskliniek  Nijmegen"},{"name":"Department of Pharmacy Radboud University Medical Center  Nijmegen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter J.","family":"Emans","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Maastricht University Medical Center  Maastricht"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arief","family":"Lalmohamed","sequence":"additional","affiliation":[{"name":"Department of Pharmacoepidemiology &amp; Clinical Pharmacology Utrecht University  Utrecht"},{"name":"Department of Clinical Pharmacy University Medical Center Utrecht  Utrecht"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthonius","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Pharmacoepidemiology &amp; Clinical Pharmacology Utrecht University  Utrecht"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelies","family":"Boonen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology Maastricht University Medical Center  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,4]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Arthritis Research UK Osteoarthritis in general practice.July 2013: 4. 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