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Maintenance dose predictions to achieve the recommended plasma urate target were generated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The urate response was best described by a direct effects model. Renal function, diuretic use and body size were found to be significant covariates. Dose requirements increased approximately 2\u2010fold over a 3\u2010fold range of total body weight and were 1.25\u20132 fold higher in those taking diuretics. Renal function had only a modest impact on dose requirements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Contrary to current guidelines, the model predicted that allopurinol dose requirements were determined primarily by differences in body size and diuretic use. A revised guide to the likely allopurinol doses to achieve the target plasma urate concentration is proposed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.12799","type":"journal-article","created":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T20:20:43Z","timestamp":1444422043000},"page":"277-289","source":"Crossref","is-referenced-by-count":52,"title":["Predicting allopurinol response in patients with gout"],"prefix":"10.1111","volume":"81","author":[{"given":"Daniel F. 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