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The mechanistic target of rapamycin (mTOR), also known as the mammalian target of rapamycin, is a 289 kDa serine\/threonine protein kinase that offers exciting possibilities for novel treatment strategies for a host of neurodegenerative diseases that include Alzheimer's disease, Parkinson's disease, Huntington's disease, epilepsy, stroke and trauma. mTOR governs the programmed cell death pathways of apoptosis and autophagy that can determine neuronal stem cell development, precursor cell differentiation, cell senescence, cell survival and ultimate cell fate. Coupled to the cellular biology of mTOR are a number of considerations for the development of novel treatments involving the fine control of mTOR signalling, tumourigenesis, complexity of the apoptosis and autophagy relationship, functional outcome in the nervous system, and the intimately linked pathways of growth factors, phosphoinositide 3\u2010kinase (PI 3\u2010K), protein kinase B (Akt), AMP activated protein kinase (AMPK), silent mating type information regulation two homologue one (\n                    <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n                    ) (SIRT1) and others. Effective clinical translation of the cellular signalling mechanisms of mTOR offers provocative avenues for new drug development in the nervous system tempered only by the need to elucidate further the intricacies of the mTOR pathway.\n                  <\/jats:p>","DOI":"10.1111\/bcp.12804","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T13:48:53Z","timestamp":1444916933000},"page":"1245-1266","source":"Crossref","is-referenced-by-count":164,"title":["Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders"],"prefix":"10.1111","volume":"82","author":[{"given":"Kenneth","family":"Maiese","sequence":"first","affiliation":[{"name":"Cellular and Molecular Signaling  Newark New Jersey 07101 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2005.02.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.139453"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567202611666140408104831"},{"key":"e_1_2_8_5_1","first-page":"1","article-title":"Death in the United States, 2011","author":"Minino AM","year":"2013","journal-title":"NCHS Data Brief"},{"key":"e_1_2_8_6_1","first-page":"46","article-title":"Global demographic shifts create challenges and opportunities","author":"Hayutin A","year":"2007","journal-title":"PREA Quarterly"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v7.i2.235"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567202612666150305110929"},{"key":"e_1_2_8_9_1","first-page":"999","article-title":"Stem cell guidance through the mechanistic target of rapamycin","volume":"7","author":"Maiese K","year":"2015","journal-title":"World J Stem Cells"},{"key":"e_1_2_8_10_1","unstructured":"World Health Organization. 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