{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:20:16Z","timestamp":1790630416743,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,17]],"date-time":"2016-01-17T00:00:00Z","timestamp":1452988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to assess the analgesic efficacy, pharmacokinetics, tolerability and safety of a single dose of \u03949\u2010THC in patients with chronic abdominal pain resulting from chronic pancreatitis (CP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a randomized, single dose, double\u2010blinded, placebo\u2010controlled, two way crossover study in patients suffering from abdominal pain as result of CP (<jats:italic>n<\/jats:italic>\u00a0=\u00a024), <jats:italic>post hoc<\/jats:italic> subdivided into opioid and non\u2010opioid users. \u03949\u2010THC (8\u00a0mg) or active placebo (5\u00a0mg\/10\u00a0mg diazepam) was administered orally in a double dummy design.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No treatment effect was shown for delta VAS pain scores after \u03949\u2010THC compared with diazepam. \u03949\u2010THC was well absorbed with a mean <jats:italic>t<\/jats:italic><jats:sub>max<\/jats:sub> of 123\u00a0min. No significant differences were found between \u03949\u2010THC <jats:italic>vs<\/jats:italic>. diazepam for alertness, mood, calmness or balance. Feeling anxious and heart rate were significantly increased after \u03949\u2010THC compared with diazepam. The most frequently reported adverse events (AEs) after \u03949\u2010THC administration were somnolence, dry mouth, dizziness and euphoric mood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A single dose of \u03949\u2010THC was not efficacious in reducing chronic pain resulting from CP, but was well tolerated with only mild or moderate AEs. The PK results in CP patients showed delayed absorption and an increased variability compared with healthy volunteers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.12811","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T18:44:48Z","timestamp":1445971488000},"page":"525-537","source":"Crossref","is-referenced-by-count":38,"title":["Single dose delta\u20109\u2010tetrahydrocannabinol in chronic pancreatitis patients: analgesic efficacy, pharmacokinetics and tolerability"],"prefix":"10.1111","volume":"81","author":[{"given":"Marjan","family":"de Vries","sequence":"first","affiliation":[{"name":"Department of Surgery Radboud University Medical Center  Nijmegen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar C. M.","family":"Van Rijckevorsel","sequence":"additional","affiliation":[{"name":"Department of Surgery Radboud University Medical Center  Nijmegen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris C. 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