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All children and adults with intentional overdoses need to be referred for medical assessment and treatment. Unintentional supratherapeutic ingestions can be initially managed at home but if symptomatic or if there is persistent hypoglycaemia require medical referral. Patients often require intensive care and prolonged observation periods. Blood glucose concentrations should be assessed frequently. Asymptomatic children with unintentional sulfonylurea ingestions should be observed for 12\u00a0h, except if this would lead to discharge at night when they should be kept until the morning. Prophylactic intravenous dextrose is not recommended. The goal of therapy is to restore and maintain euglycaemia for the duration of the drug's toxic effect. Enteral feeding is recommended in patients who are alert and able to tolerate oral intake. Once insulin or sulfonylurea\u2010induced hypoglycaemia has developed, it should be initially treated with an intravenous dextrose bolus. Following this the mainstay of therapy for insulin\u2010induced hypoglycaemia is intravenous dextrose infusion to maintain the blood glucose concentration between 5.5 and 11\u00a0mmol\u00a0l<jats:sup>\u20131<\/jats:sup>. After sulfonylurea\u2010induced hypoglycaemia is initially corrected with intravenous dextrose, the main treatment is octreotide which is administered to prevent insulin secretion and maintain euglycaemia. The observation period varies depending on drug, product formulation and dose. A general guideline is to observe for 12\u00a0h after discontinuation of intravenous dextrose and, if applicable, octreotide.<\/jats:p>","DOI":"10.1111\/bcp.12822","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T20:18:46Z","timestamp":1447100326000},"page":"496-504","source":"Crossref","is-referenced-by-count":55,"title":["Treatment of sulfonylurea and insulin overdose"],"prefix":"10.1111","volume":"81","author":[{"given":"Wendy","family":"Klein\u2010Schwartz","sequence":"first","affiliation":[{"name":"Maryland Poison Center, Department of Pharmacy Practice and Science University of Maryland School of Pharmacy  USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina L.","family":"Stassinos","sequence":"additional","affiliation":[{"name":"Maryland Poison Center, Department of Pharmacy Practice and Science University of Maryland School of Pharmacy  USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey 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